Effects of inhibition of Kupffer cell and splenectomy on thioacetamide-induced hepatic injury |
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Authors: | ZHAO Yan LIU Jin-chun HAN De-wu XU Rui-ling |
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Institution: | 1. Department of Gastroenterology, The First Clinic Hospital, Shanxi Medcial University,Taiyuan 030001, China;
2. Department of Pathophysiology, Shanxi Medcial University,Taiyuan 030001, China |
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Abstract: | AIM: To examine the effects of inhibition of Kupffer cell and splenectomy on intestinal endotoxemia and hepatic injury. METHODS: The hepatic injury model was established by treatment with thioacetamide (TAA). At the same time, inhibition of Kupffer cells by intravenous GdCl3 and splenectomy were performed. Serum alanine aminotransferase (ALT), TNF-α, endotoxin content and phagocytic index were observed. RESULTS: In the TAA+GdCl3 group, and TAA+splenectomy group, the endotoxin content was significently higher than that in normal and TAA group (P<0.05). The plasma TNF-α, ALT and total bilirubin were significantly lower than those in TAA group (P<0.05). CONCLUSION: Inhibition of Kupffer cells and splenectomy increase plasma endotoxin level, but decreases the plasma TNF-α levels and alleviates the hepatic injury induced by TAA. |
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Keywords: | Endotoxemia Kupffer cells Splenectomy Liver |
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