Relation between TNF-α,TNFR I expression and apoptosis in oral lichen planus |
| |
Authors: | SHEN Li-Jia RUAN Ping YIN Cao XIE Si-ming ZHAO Tong |
| |
Institution: | 1. Department of Stomatology, Medical College of Jinan University, Guangzhou 510632, China;
2. Department of Oral Mucosal Disease, Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China;
3. Department of Pathology, First Military Medical University, Guangzhou 510515, China |
| |
Abstract: | AIM: To examine the expression and distribution of tumor necrosis factor-α (TNF-α), tumor necrosis factor receptor I (TNFR I) and apoptosis in oral lichen planus, and evaluate their roles and relation in the oral lichen. METHODS: Immunohistochemical technique and TUNEL were employed to study the expression of TNF-α, TNFR I and apoptosis in 50 cases of oral lichen planus and 10 normal oral mucosa specimens. RESULTS: Compared with the normal control group, TNF-α expression was upregulated in mononuclear cells in lamina propria and decreased in keratinocytes in oral lichen planus lesion (P<0.05). On the contrary, TNFR I expression was increased in keratinocytes and decreased in lamina propria in oral lichen planus lesion (P<0.05). The increased apoptosis index in keratinocytes and the decreased apoptosis index in lamina propria were found in oral lichen planus (P<0.05). CONCLUSION: The accelerated apoptosis of keratinocytes and the inhibition of lymphocytes apoptosis may contribute to the formation and progression of oral lichen planus. |
| |
Keywords: | Lichen planus oral Tumor necrosis factor Receptors tumor necrosis factor Apoptosis |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|