Effect of CGRP on level of lung endogenous NO in rabbits with acute lung injury |
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| Authors: | LIAO Jian-jun LI Huan-zhang Qi Hao-wen |
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| Institution: | Respiratory Department, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China |
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| Abstract: | AIM:To examine whether calcitonin gene-related peptide (CGRP) enhances nitric oxide (NO) level in pulmonary circulation blood and observe the influence of CGRP on mean pulmonary artery pressure (mPAP) in rabbits with acute lung injury (ALI) caused by oleic acid.METHODS: The level of NO was assessed by measuring the presence of nitrite in cervical artery blood by the Griess reaction, mPAP was measured with right ventricular catheter.RESULTS:The level of nitrite in cervical artery blood was significantly increased and the mPAP was markedly reduced after administration of CGRP intravenousely.CONCLUSION:CGRP enhanced the NO level of pulmonary circulation blood and reduces the mPAP significantly in rabbits with ALI. |
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| Keywords: | Calcitonin gene-related peptide Respiratory distress syndrom Nitric oxide Rabbits |
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