Cortical gene expression pattern in rat focal cerebral ischemia |
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| Authors: | ZHANG Zhan-jun YING Kang WANG Zhong ZHANG Xiao-yan LIU Jian-xun HUANG Yan XU Li WEI Cui-e WANG Yong-yan |
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| Institution: | 1. The Clinical School of Beijing University of Traditional Chinese Medicine, Beijing 100029, China;
2. The Academy of Shanghai Lian He Gene Group, Shanghai 200000, China;
3. Xi Yuan Hospital of The Academe of Traditional Chinese Medicine, Beijing 100091, China;
4. Beijing Normal University, Beijing 100037, China;
5. The Academy of Traditional Chinese Medicine, Beijing 100089, China |
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| Abstract: | AIM: To investigate the genes differential expression in cortex during rat focal cerebral ischemia.METHODS: cDNA microarray chips containing numerous cDNAs were used to investigate the gene expression pattern between samples of focal cerebral ischemia and sham-control operation rats. RESULTS: Two hundred and eleven genes differentially expressed were screened out, among these genes, up-and down-regulated genes were 199 and 12, respectively. CONCLUSIONS: The analysis of gene expression pattern of focal cerebral ischemia based on cDNA microarray can realize high-throughput screening of the genes associated with the focal cerebral ischemia. The differential expression of genes may be related to the pathogenesis of focal cerebral ischemic diseases. |
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| Keywords: | Brain ischemia Gene expression profiling Oligonucleotide array sequence analysis Rats |
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