Role of vascular NAD(P)H oxidase in vascular remodeling |
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| Authors: | CHEN Wen-dong GAO Ping-jin ZHU Ding-liang |
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| Institution: | Shanghai Institute of Hypertension, Shanghai Second Medical University, Shanghai 200025, China |
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| Abstract: | NAD(P)H oxidase was initially found in phagocytes and it participates in the generation of reactive oxygen species(ROS). Recent researches have showed that NAD(P)H oxidase also expresses in other tissues including blood vessels and it plays a critical role in vascular remodeling through ROS which are important signaling molecules in vascular cells.This article reviews the biochemical characterization, activation paradigms, structure, and function of this enzyme. |
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| Keywords: | NADPH oxidase Reactive oxygen species Vascular remodeling |
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