The molecular mechanism of inhibition of murine Lewis lung carcinoma metastasis by weimaining in vivo |
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| Authors: | LOU Jin-li LIN Hong-sheng QIU Quan-ying PEI Ying-xia QI Xin HE Xiu-juan |
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| Institution: | 1. Department of Microbiology and Immunology, Beijing University of Chinese Medicine, Beijing 100029, China;
2. Tumor Laboratory of Guanganmen Hospital, The China Academy of Traditional Chinese Medicine, Beijing 100053, China |
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| Abstract: | AIM: To investigate the anti-metastasis effect of weimaining, extracted from fragopyrum cymosum meissn, a Chinese medicine, on murine Lewis lung carcinoma (3LL). METHODS: The anti-metastasis effect of weimaining in vivo was detected in the grafting lung metastasis model of murine Lewis lung carcinoma. The effects of the drug on the expression of CD34 and E-cadherin were investigated by immunohistochemical staining and RT-PCR. RESULTS: Weimaining effectively inhibited the lung metastasis of 3LL at a concentration of 250 mg·kg-1·d-1, significantly suppressed the expression of CD34 and increased the expression levels of E-cadherin protein and mRNA in 3LL cells. CONCLUSIONS: Weimaining inhibits the metastasis of murine Lewis lung carcinoma (3LL) in vivo via increasing the expression of E-cadherin and decreasing microvessel density of tumor tissue. |
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| Keywords: | Weimaining Neoplasm metastasis Cadherins Antigens CD34 |
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