Angiopoietin-1 and regulation of vascular permeability |
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Authors: | YUE Fei JIN Hui-ming |
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Institution: | Department of Physiology & Pathophysiology, Fudan University Shanghai Medical College, Shanghai 200032, China |
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Abstract: | Angiopoietin-1 (Ang-1) is a newly-found endothelium-specific proangiogenic factor and it had been proved essential roles in both vasculogenesis and angiogensis. Among them, its anti-leakage ability may have great potential applications in clinical treatment of vascular hyper-permeability in a variety of diseases such as cancer, diabetic retinopathy, rheumatoid arthritis, asthma. In this review, some research progresses focused on this aspect are discussed. |
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Keywords: | Angiopoietin Endothelial cells Capillary permeability |
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