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Influence of bifidobacterium on NF-κB and I κBα of experimental large bowel carcinoma |
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| Authors: | WANG Li-sheng ZHU Hui-ming PAN Ling-jia HUANG Xun LUO Wei-xiang MA Xiao-dong ZHUANG Ya-li ZHOU Dian-yuan |
| Institution: | 1. Department of Gastroenterology, The Second Affiliated Hospital, Jinan University of Medicine, Shenzhen 518020, China; 2. PLA Institute for Digestive Medicine, Nanfang Hospital, Guangzhou 510515, China; 3. Center Laboratory of Background Department, First Military Medical University, Guangzhou 510515, China |
| Abstract: | AIM:To explore the antitumor mechanisms of bifidobacteria adolescence in vivo. METHODS:The activity of NF-κB and its inhibiting protein I κBα of large bowel carcinoma tissues was detected by using laser scanning confocal microscope and immunohistochemistry.RESULTS:The positive cell density of NF-κB of large bowel carcinoma transplantation tumors in bifidobacterium injection group was markedly lower than that in tumor control group(P＜0.01).The expression of I κBα was contary in the two group. The average fluorescent strength of I κBα of large bowel carcinoma in bifidobacterium injection group was significantly higher than that in tumor control group(P＜0.01).CONCLUSION:Bifidobacteria adolescence could inhibit the degrade of I κBα and the activition of NF-κB in large bowel carcinoma in vivo. |
| Keywords: | Bifidobacterium Intestinal neoplasms NF-kappa B |
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