Therapeutic effects of recombinant human growth hormone on rat sepsis |
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| Authors: | HUANG Ying WANG Shu-ren YING Ming-ying ZHI Mao-hui LIN Ying |
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| Institution: | 1. Department of Pathophysiology, Chengdu 610041, China;
2. ICU of Huaxi Hospital, Sichuan University, Chengdu 610041, China;
3. Laboratory of Functional Sciences, Huaxi School of Basic Medical Sciences and Forensic Medicine, Chengdu 610041, China |
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| Abstract: | AIM:To investigate therapeutic effects of recombinant human growth hormone(rhGH) on rat sepsis and its possible mechanisms.METHODS:Mean arterial pressure (MAP), levels of plasma TNFα, IL-1β and endotoxin, leukocyte count and survival rate within 1 week were determined after E. coli injection among control group, sepsis group and sepsis+rhGH group.RESULTS:(1)rhGH diminished the decrease of MAP, reduced plasma endotoxin and TNFα levels and increased neutrophil ratio in total leukocytes in sepsis rat. rhGH increased survival rate within 1 week on sepsis rat. (2)No changes were found in IL-1β level among the three groups.CONCLUSION:rhGH showed desirable beneficial effects on rat sepsis, which may attribute to: improving circulatory function;maintaining intestinal mucosa barrier, attenuating bacteria/endotoxin translocation and inhibiting the production and release of TNFα. |
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| Keywords: | Sepsis Growth hormone Survival rate Endotoxins Tumor necrosis factor Interleukin-1 |
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