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| 羊口疮病毒活载体疫苗和生物制剂的研制现状 | |
| 引用本文： | 张凯照,于梦,宁章勇. 羊口疮病毒活载体疫苗和生物制剂的研制现状[J]. 中国畜牧兽医, 2015, 42(9): 2499-2505. DOI: 10.16431/j.cnki.1671-7236.2015.09.042 |
| 作者姓名： | 张凯照 于梦 宁章勇 |
| 作者单位： | 1. 华南农业大学兽医学院, 广州 510642; 2. 广东省兽医临床重大疾病综合防控重点实验室, 广州 510642 |
| 基金项目： | 广东省自然科学基金(s2013010013041) |
| 摘 要： | 羊口疮病毒的基因组结构、编码基因复制特性及其在宿主和非宿主体内快速启动机体的免疫反应特点,使其具有作为活病毒疫苗载体的特殊优势。此外,该病毒自身及其编码蛋白的双向免疫调节功能使其具有作为临床使用生物制剂的巨大潜力。作者对基于羊口疮病毒的重组疫苗和生物制剂的研制现状进行了详细的综述,以期为该病毒的疫苗研制、生物制剂研发及临床应用提供参考。 |
| 关 键 词： | 羊口疮病毒 活载体疫苗 生物制剂 |
| 收稿时间： | 2015-02-10 |
Research Status on the Development of Live Vector Vaccine and Biological Agents of Orf Virus |
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| ZHANG Kai-zhao,YU Meng,NING Zhang-yong. Research Status on the Development of Live Vector Vaccine and Biological Agents of Orf Virus[J]. China Animal Husbandry & Veterinary Medicine, 2015, 42(9): 2499-2505. DOI: 10.16431/j.cnki.1671-7236.2015.09.042 | |
| Authors: | ZHANG Kai-zhao YU Meng NING Zhang-yong |
| Affiliation: | 1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China; 2. Key Laboratory of Comprehensive Prevention and Control of Veterinary Clinical Major Diseases, Guangzhou 510642, China |
| Abstract: | Orf virus (ORFV) has special advantages as the live viral vaccination vectors due to its structure of genome, replication characteristics of encoding gene and quick activation of immunoreactions in host and non-host.In addition, ORFV and its coding proteins have huge potential as clinical biological agents for their function as dual immune modulators.Research statuses on recombinant vaccine of ORFV and biological agents were reviewed which would provide the reference for the development and clinical application of vaccination and biological agents. |
| Keywords: | Orf virus (ORFV) live vector vaccine biological agents |
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