| 2-杂环基-1,3,4-噁二嗪酮类化合物的合成及其除草活性 |
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| 引用本文： | 潘玲玲,沈晓霞,曹瑾,陈亮,沈宙,袁莉萍,张一宾.2-杂环基-1,3,4-噁二嗪酮类化合物的合成及其除草活性[J].农药学学报,2011,13(3):239-244. |
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| 作者姓名： | 潘玲玲 沈晓霞 曹瑾 陈亮 沈宙 袁莉萍 张一宾 |
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| 作者单位： | 1.华东理工大学 药学院,上海 200237 |
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| 基金项目： | "十一五"国家科技支撑计划项目 |
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| 摘 要： | 以取代杂环羧酸为起始原料,在1,3,4-噁二嗪-5-酮的2-位上分别引入呋喃环、吡啶环及氯代噻吩环,合成了31个未见报道的2-杂环基-1,3,4-噁二嗪酮化合物,其化学结构经核磁共振氢谱和元素分析确证。初步的生物活性测定结果表明,该类化合物具有良好的除草活性,如在质量浓度200 mg/L时,化合物 E14、E16、E20、E21 对马唐Digitaria sanguinalis的抑制率大于90%,化合物 E06、E07、E10、E14、E16、E20 对苋菜Ambrosia tricolor的抑制率也大于90%。
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| 关 键 词： | 1 3 4-噁二嗪-5-酮 有机合成 除草活性 |
| 收稿时间： | 2010/12/20 0:00:00 |
| 修稿时间： | 2011/1/10 0:00:00 |
Synthesis and herbicidal activity of 2-heterocyclic- 1,3,4-oxadiazine-5-ones |
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| PAN Ling-ling,SHEN Xiao-xi,CAO Jin,CHEN Liang,SHEN Zhou,YUAN Li-ping and ZHANG Yi-bin.Synthesis and herbicidal activity of 2-heterocyclic- 1,3,4-oxadiazine-5-ones[J].Chinese Journal of Pesticide Science,2011,13(3):239-244. |
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| Authors: | PAN Ling-ling SHEN Xiao-xi CAO Jin CHEN Liang SHEN Zhou YUAN Li-ping and ZHANG Yi-bin |
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| Institution: | 1.Pharmaceutical Institute,East China University of Science and Technology,Shanghai 200237,China2.Shanghai Pesticide Research Institute,Shanghai 200032,China |
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| Abstract: | Thirty one novel compounds of 2-heterocyclic-1,3,4-oxadiazine-5-one derivatives were synthesized through the starting material substituted heterocyclic carboxylic acid.The structure of all compounds was confirmed by 1H NMR and elemental analysis.The preliminary assays showed that some compounds exhibited significant herbicidal activity.The inhibition rate of E14,E16,E20 and E21 to the Digitaria sanguinalis and E06,E07,E10,E14,E16 and E20 to the Ambrosia tricolor reached 90% at the mass concentration of 200 mg/L. |
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| Keywords: | 1 3 4-oxadiazine-5-one synthesis herbicidal activity |
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