| 小鼠鼻粘膜接种伤寒杆菌Fe-SOD的抗体应答 |
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| 引用本文： | 唐湘涓 徐军发 凌天翼. 小鼠鼻粘膜接种伤寒杆菌Fe-SOD的抗体应答[J]. 湛江医学院学报, 2005, 23(1): 14-16 |
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| 作者姓名： | 唐湘涓 徐军发 凌天翼 |
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| 作者单位： | 广东医学院检验学院临床免疫学教研室,广东湛江,524023;贵阳医学院免疫学教研室,贵州贵阳,550004 |
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| 基金项目： | 湛江市科技攻关项目 (ZK0 1 2 3) |
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| 摘 要： | 目的：观察小鼠鼻腔接种伤寒杆菌的Fe—SOD后血液和粘膜系统的抗体应答。方法：用IL-1作为佐剂，将伤寒杆菌的Fe—SOD经鼻腔接种小鼠，检测小鼠血液及肠液中的抗体应答。结果：当用IL-1作为佐剂时，经鼻腔接种伤寒杆菌Fe—SOD的小鼠血液和肠液中可产生高水平特异性IgG和IgA类抗体；而腹腔注射仅在血液中产生高水平特异性IgG抗体。结论：用IL-1作为佐剂，伤寒杆菌Fe—SOD经鼻腔接种后可引起小鼠粘膜系统和血液中的抗体应答。
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| 关 键 词： | 伤寒杆菌 Fe-SOD 粘膜 抗体应答 |
| 文章编号： | 1005-4057(2005)01-0014-03 |
| 修稿时间： | 2004-05-08 |
Antibody response induced by intranasal immunization with Salmonella typhi Fe-SOD in mice |
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| TANG Xiang-juan ,XU Jun-fa ,LING Tian-yi. Antibody response induced by intranasal immunization with Salmonella typhi Fe-SOD in mice[J]. Journal of Guangdong Medical College, 2005, 23(1): 14-16 |
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| Authors: | TANG Xiang-juan XU Jun-fa LING Tian-yi |
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| Affiliation: | TANG Xiang-juan 1,XU Jun-fa 1,LING Tian-yi 2 |
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| Abstract: | Objective:To observe the antibody response induced by intranasal administration of S. typhi Fe-SOD in mice. Methods: The mice were immunized by intranasal administration or abdominal injection of S. typhi Fe-SOD and interleukin-1 (IL-1). The antibody against Fe-SOD in serum and intestinal juice was detected by ELISA. Results: Intranasal immunization induced high levels of IgG and IgA against Fe-SOD in mouse serum and intestinal juice, whereas abdominal injection only induced high levels of IgG in serum. Conclusion: Intranasal immunization with S. typhi Fe-SOD and IL-1 is able to induce antibody response in serum and intestinal mucosa. |
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| Keywords: | Salmonella typhi Fe-SOD mucosa antibody response |
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