Sporiolides A and B,New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species |
| |
| Authors: | Hideyuki Shigemori Yuu Kasai Kazusei Komatsu Masashi Tsuda Yuzuru Mikami Jun’ichi Kobayashi |
| |
| Affiliation: | 1.Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan;2.Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan |
| |
| Abstract: | ![]()
Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa. |
| |
| Keywords: | marine-derived fungus Cladosporium sp. macrolide cytotoxic |
|
|
