莲藕多糖的降血糖活性及对体内抗氧化能力的影响

[目的]研究莲藕（RHIZOMA NELUMBINIS NUCIFERAE）糖对糖尿病小鼠的降糖效果及其对体内抗氧化能力的影响。[方法]采用四氧嘧啶诱导糖尿病小鼠动物模型。试验设正常对照组、糖尿病对照组、优降糖对照组及莲藕多糖低、中、高剂量组。[结果]莲藕多糖能减缓糖尿病小鼠消瘦的症状,降低血糖,提高糖尿病小鼠葡萄糖耐受能力。此外,莲藕多糖还可不同程度地提高糖尿病小鼠肝、肾和胰腺等重要组织的SOD活性,降低MDA含量。[结论]该研究可为新的天然降糖药物的开发提供理论依据。

Hypoglycemic Activity of RHIZOMA NELUMBINIS NUCIFERAE Polysaccharide and Its Effect on In Vivo Antioxidant Activity

[Objective] To investigate the hypoglycemic efficiency of(RHIZOMA NELUMBINIS NUCIFERAE) polysaccharide on diabetic rats,and its in vivo antioxidant activity.[Method] Alloxan-induced diabetic rats were used to be animal model,and normal control group,diabetes control group,glybenzcyclamide control group,and low-dose,middle-dose and high-dose group of(RHIZOMA NELUMBINIS NUCIFERAE)polysaccharide were employed in this study.[Result](RHIZOMA NELUMBINIS NUCIFERAE) polysaccharide showed efficacies on relieving emaciation of diabetic rats,lowering blood sugar and promoting the glucose endurance of diabetic rats.In addition,it also possessed effects on increasing SOD activity of diabetic rats′ liver,kidney and pancreas etc.,and on reducing the content of MDA.[Conclusion] This study provides theoretical evidence for the development of new natural hypoglycemic drugs.