| N-甲氧基-N- 苯基氨基甲酸甲酯的合成及生物活性研究 |
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| 引用本文： | 刘卫东,李江胜,李仲英,王晓光,高必达.N-甲氧基-N- 苯基氨基甲酸甲酯的合成及生物活性研究[J].农药学学报,2004,6(1):17-21. |
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| 作者姓名： | 刘卫东 李江胜 李仲英 王晓光 高必达 |
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| 作者单位： | 1.湖南省化工研究院,湖南 长沙 410007 |
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| 摘 要： | 为了寻找新的高效的Strobilurin类杀菌剂,以1-取代基-3-三氟甲基吡唑啉-5-酮与N-甲氧基-N-(2-溴甲基苯基)氨基甲酸甲酯反应,合成了系列新型N-甲氧基-N- 苯基氨基甲酸甲酯化合物 (IV1~IV13) ,其结构经IR、1H NMR、LC/MS及元素分析确认。生物活性测定结果表明,该类化合物在50 mg/L下对稻瘟病菌Pyricularia oryzae、黄瓜灰霉病菌Botrytis cinerea、小麦白粉病病菌Erysiphe graminis等具有较高的抑菌活性,如 IV13 对稻瘟病菌P.oryzae 的抑制率达94.0%.
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| 关 键 词： | 吡唑 N-甲氧基氨基甲酸酯 合成 杀菌活性 |
| 文章编号： | 1008-7303(2004)01-0017-05 |
| 收稿时间： | 2003/10/23 0:00:00 |
| 修稿时间： | 2003年10月23 |
Synthesis and Fungicidal Activity of Methyl N-methoxy-N- phenylcarbamates |
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| LIU Wei-dong,LI Jiang-sheng,LI Zhong-ying,WANG Xiao-guang and GAO Bi-da.Synthesis and Fungicidal Activity of Methyl N-methoxy-N- phenylcarbamates[J].Chinese Journal of Pesticide Science,2004,6(1):17-21. |
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| Authors: | LIU Wei-dong LI Jiang-sheng LI Zhong-ying WANG Xiao-guang and GAO Bi-da |
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| Institution: | 1.Hunan Research Institute of Chemical Industry, Changsha 410007,China2.College of Chemistry and Chemical Engineering,Hunan University, Changsha 410082, China3.Hunan Agricultural University,Changsha 410128, China |
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| Abstract: | A series of novel methyl N-methoxy-N-2-(3-trifluoromethyl)-1-substituted pyrazol-5-yloxylmethylene]phenylcarbamates were synthesized from 3-trifluoromethyl-1-substituted(pyrazolin)-5-one and methyl N-methoxy-N-(2-bromomethylphenyl)carbamates. All novel (compounds) were confirmed by ()~1H NMR,IR and LC/MS.The preliminary bioassays showed that some compounds had fungicidal activities to Pyricularia oryzae, Botrytis cinerea, and Erysiphe graminis under 50 mg/L,for example,the inhibitory ratio of compound IV_(13) to P. oryzae was 94%. |
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| Keywords: | pyrazole N-methoxylcarbamates synthesis fungicidal activity |
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