| 海洋共生菌Aspergillus sp.HDf2新活性次生代谢产物研究(英文) |
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| 引用本文： | 王 蓉,符致德,何晓娜,唐贤明,李向民,郭志凯.海洋共生菌Aspergillus sp.HDf2新活性次生代谢产物研究(英文)[J].热带作物学报,2014,35(8):1658-1662. |
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| 作者姓名： | 王 蓉 符致德 何晓娜 唐贤明 李向民 郭志凯 |
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| 作者单位： | 海南省海洋与渔业科学;海南省海洋与渔业科学;海南省海洋与渔业科学;海南省海洋与渔业科学;海南省海洋与渔业科学;中国热带农业科学院热带生物技术研究所农业部热带作物生物学与遗传资源利用重点实验室 |
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| 基金项目： | 海南省自然科学基金项目(No.314176，No.313079)。 |
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| 摘 要： | 对紫海胆共生真菌Aspergillus sp.HDf2的次生代谢产物进行分离和鉴定。采用摇瓶液体发酵,运用柱层析等方法对其发酵液成分进行分离纯化,经波谱解析和质谱分析进行结构鉴定,并运用滤纸片法对化合物进行体外抗金黄色葡萄球菌的活性测试。结果从该真菌发酵产物中鉴定出2个secospiculisporic acid新类似物,分别为secospiculisporic acid B(1)和secospiculisporic acid C(2),其中化合物1具有弱抗菌活性,抑菌直径为9.2 mm(20 mg/mL)。首次对化合物1的NMR数据进行了归属,化合物2为secospiculisporic acid类的新化合物。
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| 关 键 词： | 曲霉菌 海洋真菌 secospiculisporic acid 抗菌活性 |
New Secondary Metabolites Produced by the Marine-derived Fungus Aspergillus sp. HDf2 |
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| WANG Rong,FU Zhide,E Xiaon,TANG Xianming,LI Xiangmin and GUO Zhikai.New Secondary Metabolites Produced by the Marine-derived Fungus Aspergillus sp. HDf2[J].Chinese Journal of Tropical Crops,2014,35(8):1658-1662. |
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| Authors: | WANG Rong FU Zhide E Xiaon TANG Xianming LI Xiangmin and GUO Zhikai |
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| Institution: | Hainan Academy of Ocean and Fisheries Sciences;Hainan Academy of Ocean and Fisheries Sciences;Hainan Academy of Ocean and Fisheries Sciences;Hainan Academy of Ocean and Fisheries Sciences;Hainan Academy of Ocean and Fisheries Sciences;Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture/Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences |
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| Abstract: | The sea urchin(Anthocidaris crassispina)associated fungus Aspergillus sp. HDf2 was cultivated in liquid media, and its bioactive secondary metabolites were investigated. Chromatographic separations of silica gel were used, and the structures of the secondary metabolites were elucidated on the basis of spectroscopic analysis. The antibacterial activity of the compounds against Staphylococcus aureus was conducted. As a result, two unreported secospiculisporic acid derivatives, secospiculisporic acid B(1)and secospiculisporic acid C(2), were isolated and identified. Compound 1 showed weak antibacterial activity against Staphylococcus aureus with inhibition zone of 9.2 mm at 20 mg/mL. The full NMR data assignment of compound 1 is reported for the first time, while compound 2 is a new secospiculisporic acid derivative. |
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| Keywords: | Aspergillus sp Marine fungus Secospiculisporic acid Antibacterial activity |
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