Phenotypic analysis of hepatic T lymphocytes in a dog with chronic hepatitis |
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| Authors: | Sakai Manabu Otani Isao Ishigaki Kumiko Edamura Kazuya Takahashi Tomoko Koie Hiroshi Yamaya Yoshiki Watari Toshihiro Shibuya Hisashi Sato Tsuneo Kanayama Kiichi Tokuriki Mikihiko Hasegawa Atsuhiko |
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| Affiliation: | Laboratory of Comprehensive Veterinary Clinical Studies, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University, Kanagawa, Japan. |
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| Abstract: | We evaluated hepatic T lymphocyte phenotypes in a dog with chronic hepatitis. Before treatment, numerous CD3+ lymphocytes were demonstrated in the liver, and the ratio of CD4+/CD8+ was remarkably high (2.96; reference range, 0.33+/-0.12). After treatment, CD3+ lymphocyte infiltration in the liver was reduced, and the ratio of CD4+/CD8+ decreased to 0.31. Therefore, hepatic T lymphocytes, especially CD4+ lymphocytes, might play a central role in the pathogenesis of this dog with chronic hepatitis. |
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