转移因子与重组转移因子及其在疾病防治中的应用

转移因子是来自于免疫淋巴细胞的一类可透析小分子多肽,它能够将致敏淋巴细胞的免疫信息传递给未致敏的受体淋巴细胞。转移因子具有特异性和非特异性免疫活性,特异性转移因子具有转移特异性细胞免疫的能力,非特异性转移因子具有促进淋巴细胞活化增殖,增强其免疫活性,并可诱导靶细胞产生大量的细胞因子。重组转移因子是利用基因工程技术将编码具有免疫增强活性的转移因子基因,进行克隆和体外表达,表达产物经纯化制备而成,试验表明其具有增强细胞免疫活性的作用。转移因子和重组转移因子是一种具有免疫增强活性的新型高效安全的生物药品,在临床上用于疾病的防治,具有广阔的应用前景。

Transfer Factor and Recombinant Transfer Factor and Its Applications in Prevention of Diseases

Transfer factors(TF) are low molecular weight-dialysable small polypeptides extracted from immune cells which transmit immunologic information from sensitized donors to nonimmnune recipients.Contact with transfer factor molecules on a first encounter with antigen would allow a naive recipient to make a secondary immunological response.Transfer factors has been proven to safely boost immune system and enhance cell-mediated immunity and stimulate the target-cell to produce abundant cytokines.Preparations of recombinant transfer factor were produced through genetic engineering and experiments of the purified rTF confirm its biological activity.A majority of researches related to transfer factors opened up great prospects for clinical applications as efficient and bio-secure immunotherapy to prevent and cure diseases.