Molecular evolution of porcine reproductive and respiratory syndrome virus isolates from central China |
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| Affiliation: | 1. College of Life Science, Hebei University, Baoding, Hebei Province 071002, China;2. College of Public Health, Hebei University, Baoding, Hebei Province 071002, China;3. College of Medicine, Hebei University, Baoding, Hebei Province 071002, China;1. Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China;2. Department of Radiation Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China |
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| Abstract: | ![]()
To investigate the genetic diversity of prevailing porcine reproductive and respiratory syndrome virus (PRRSV) in Henan Province of China, 61 ORF5 gene sequences, originating from Henan Province during 2003–2010, were subjected to amino acid variation and phylogenetic analysis. The analyzed PRRSV ORF5 sequences carried evidence of one unique recombination event. Phylogenetic analysis revealed that all Henan isolates belonged to type 2 genotype and were divided into two subgroups. The dominant isolates had shifted from subgroup 1 to subgroup 2 during 2003–2010. Amino acid variation analysis of the glycoprotein 5 revealed that Henan PRRSV strains tended to accumulate more substitutions within the N-terminus and hypervariable region. Selective pressure analysis revealed evidence that some ORF5 sites have likely evolved in response to immune pressure. |
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| Keywords: | PRRSV ORF5 Genetic variation Phylogenetic analysis |
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