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Effects of isoflurane upon minimum alveolar concentration and cerebral cortex depression in pigs and goats: An interspecies comparison |
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| Authors: | Henning A. Haga Birgit Ranheim Claudia Spadavecchia |
| Affiliation: | 1. Department of Veterinary Medicine, National Taiwan University, Taipei 110, Taiwan, ROC;2. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC;3. Dental Department, Wan-Fang Hospital, Taipei Medical University, Taipei 110, Taiwan, ROC;4. Center for Teeth Bank and Dental Stem Cell Technology, Taipei Medical University, Taipei 110, Taiwan, ROC;5. School of Dental Technology, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan, ROC;1. Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA;2. Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA;1. Maisonneuve-Rosemont Hospital affiliated to the University of Montreal, 5415 boul. L''Assomption, Montreal, (QC), H1T 2M4, Canada;2. University College London Hospitals NHS Foundation Trust, 235 Euston Road, London, NW1 2BU, United Kingdom |
| Abstract: | This study compared the effects of isoflurane in pigs (n = 10 Yorkshire–Landrace cross) and dairy goats (n = 10) by evaluation of electroencephalographic (EEG) burst suppression thresholds (BST) in the cerebral cortex and minimum alveolar concentration (MAC) values in the spinal cord. The study also investigated whether individual MAC values can predict the effects of isoflurane on the cerebral cortex. MAC values and BST/MAC ratios were significantly different between species. Inhibition of movement by isoflurane may be less effective in pigs than in goats. No significant correlation was found between individual MAC and BST values, indicating that in single animals the individual MAC poorly reflects the cerebrocortical depressant effect of isoflurane in pigs and goats. |
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