动物脂肪沉积程序化及精氨酸的调控作用

脂肪的过度沉积常伴随着胰岛素抵抗、Ⅱ型糖尿病等代谢病症,既危害人类健康,带来经济负担,也会在农业生产中影响畜牧产品的质量。脂肪的沉积,始于胚胎期脂肪组织的发育,是一系列程序化作用的结果。脂肪沉积受多方因素影响,营养干预可以通过胚胎环境中的糖皮质激素浓度、线粒体功能、表观遗传、食欲中枢发育等方面影响胚胎脂肪沉积程序化。论文阐述了动物出生前后营养状况对脂肪沉积程序化的作用,对脂肪沉积的机制进行了初步探讨,并介绍了精氨酸营养在脂肪沉积中的应用。饮食中添加精氨酸为治疗脂肪过度沉积,提高畜牧生产水平,改善人类生活质量,开拓了新的思路。

Programming of Fat Tissue Deposition and Modulation of Arginine

The excessive deposition of fat is often associated with insulin resistance and type Ⅱ diabetes, which jeopardizes human health,costs additional expenditures,and affects the quality of livestock products. The deposition of fat originates from fetal development,which is the result of a series of programming.Fat deposition is under the influence of various factors,in which,the nutrition can modulate the fetal glucocor-ticoid level,the mitochondrial function,the epigenetics,the development of appetite,and program the fat deposition.This article dealt with the effects of perinatal nutritional status on the programming of fat depo-sition,provided us preliminary study on the fat deposition,and introduced the application of arginine on the fat deposition.Arginine supplement provided a new way for curing the excessive fat deposition,improving the livestock production and improving the quality of human life.