Ganoderic acid Df,a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum |
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| Authors: | Sri Fatmawati Kuniyoshi Shimizu Ryuichiro Kondo |
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| Institution: | 1. Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, 812-8581;2. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sepuluh Nopember Institute of Technology, Kampus ITS-Sukolilo, Surabaya, Indonesia, 60111 |
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| Abstract: | Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human aldose reductase inhibitory activity, with an IC50 of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active. |
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| Keywords: | Ganoderma lucidum Aldose reductase inhibitor Ganoderic acid |
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