New triterpenoid saponins from Leontice smirnowii |
| |
Authors: | Nino Tabatadze Sok-Siya Bun Badri Tabidze Vakhtang Mshvildadze Genri Dekanosidze Evelyne Ollivier Riad Elias |
| |
Institution: | 1. Institute of Pharmacochemistry, Academy of Sciences of Georgia, 36, St. P. Sarajishvili, 0159, Tbilisi, Georgia;2. Laboratory of Pharmacognosy and Ethnopharmacology, UMR-MD3, Faculty of Pharmacy, University of the Mediterranean Aix-Marseille II, 27 Bd Jean Moulin, 13385 Marseille cedex 5, France |
| |
Abstract: | Three new triterpene saponins, leonticins I (1), J (2) and L (3) were isolated from the tubers of Leontice smirnowii. On the basis of spectroscopic methods, including 2D NMR experiments (DEPT, gs-COSY, gs-HMQC, gs-HMBC and gs-HSQC-TOCSY), mass spectrometry (HR-ESI-MS) and chemical degradation, the structures of the new compounds were elucidated as 3-O-β-D-glucopyranosyl-(1 → 3)-β-D-xylopyranosyl-1 → 2)]-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl]-3β-hydroxy-30-norolean-12,20(29)-dien-28-oic acid (1), 3-O-β-D-xylopyranosyl-(1 → 3)-β-D-galactopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 3)-α-L-arabinopyranosyl]-28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl]-3β-hydroxy-30-norolean-12,20(29)-dien-28-oic acid (2) and 3-O-β-D-xylopyranosyl-(1 → 3)-β-D-galactopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 3)]-β-D-xylopyranosyl-(1 → 2)]-α-L-arabinopyranosyl]-28-O-α-L-rhamnopyranosyl-(1 → 4)-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranosyl]-3β-hydroxy-30-norolean-12,20(29)-dien-28-oic acid (3), respectively. The aglycone 3β-hydroxy-30-norolean-12,20(29)-dien-28-oic acid was observed for the first time in Leontice species. |
| |
Keywords: | Leontice smirnowii Berberidaceae Triterpenoid saponin Leonticin |
本文献已被 ScienceDirect 等数据库收录! |
|