Phytocomplexes from liquorice (Glycyrrhiza glabra L.) leaves--chemical characterization and evaluation of their antioxidant, anti-genotoxic and anti-inflammatory activity |
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| Authors: | Siracusa Laura Saija Antonella Cristani Mariateresa Cimino Francesco D'Arrigo Manuela Trombetta Domenico Rao Felice Ruberto Giuseppe |
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| Institution: | a Istituto del C.N.R. di Chimica Biomolecolare, Via Paolo Gaifami, 18 I-95126 Catania, Italy;b Dipartimento Farmaco-Biologico, Università di Messina, Contrada Annunziata, I-98168 Messina, Italy;c Rao Erbe, Via Vincenzo Bellini, 31 I-95027 S. Gregorio di Catania, CT, Italy |
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| Abstract: | Three extracts of different polarities of Glycyrrhiza glabra L. leaves were characterized and evaluated for their antioxidant, anti-genotoxic and anti-inflammatory activity. In total, thirty components have been identified and quantified through the use of liquid chromatography (LC) with ultraviolet-visible diode-array-detector (UV-vis-DAD) and mass spectrometry (MS). The main components belong to the polyphenols family, being flavonoid and dihydrostilbene derivatives. The extracts have been investigated for their antioxidant, anti-genotoxic and anti-inflammatory activities, which are fundamental requirements of efficacious chemo-preventive agents. The ethyl acetate extract proved to be the most valuable, evidently for the conspicuous presence of several polyphenols, namely flavonoids and dihydrostilbenes. |
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| Keywords: | Glycyrrhiza glabra L Dihydrostilbenes Flavonoids Antigenotoxic Anti-inflammatory LC-UV-vis-ESI-MS |
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