Effect of colostrum redox balance on the oxidative status of calves during the first 3 months of life and the relationship with passive immune acquisition |
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| Authors: | Ángel Abuelo María Pérez-Santos Joaquín Hernández Cristina Castillo |
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| Institution: | 1. Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada;2. Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN 55108, United States;3. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada;1. Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun 130062, Jilin, China;2. College of Animal Science and Technology, Inner Mongolia National University, Tongliao 028042, China;1. Department of Emergency and Organ Transplantation, University of Bari “Aldo Moro”, strada prov.le per Casamassima km3, 70010 Valenzano, BA, Italy;2. Department of Veterinary Medicine, University of Bari “Aldo Moro”, strada prov.le per Casamassima km3, 70010 Valenzano, BA, Italy;2. Department of Veterinary Population Medicine, University of Minnesota, St. Paul 55108;3. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, N1G 2W1;1. Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, G300 Veterinary Medical Center, East Lansing, MI 48824, USA;2. Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 736 Wilson Road, D202 Veterinary Medical Center, East Lansing, MI 48824, USA |
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| Abstract: | New-born calves depend upon colostrum intake for the acquisition of immunoglobulins (Ig) and other beneficial substances. However, colostrum is also a source of reactive oxygen species (ROS). Intrinsic production of ROS also increases after birth, so the combination of colostral and intrinsic ROS could overwhelm the antioxidant capacity of the calf leading to oxidative stress (OS), a condition that has been shown to play a key role in the initiation and development of several pathological conditions.The aim of this observational study was to assess the effects of the redox balance of colostrum on the oxidative status of calves and on passive immune transfer. Serum samples were taken from 20 calves on their day of birth, every week during their first month of life and at 2 and 3 months of age, and the concentrations of ROS and serum antioxidant capacity (SAC) assayed. The oxidative/anti-oxidative profile and IgG content of the colostrum were also assessed.The redox balance of the colostrum had a significant effect on both calf oxidative status and on passive immune transfer (as measured by calf serum IgG concentration), which indicates that the oxidative/antioxidative profile of colostrum should be measured when colostrum quality is assessed. The highest risk of OS during the study period was found to be when the calves were fed artificial milk replacer; this suggests that calves should be supplemented with antioxidants during this period in order to minimize any harmful consequences of high ROS generation. |
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| Keywords: | Passive immune transfer Oxidative stress Antioxidants Immunoglobulin G Calf milk replacer |
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