Development of a severity scoring system for acute haemorrhage in anaesthetized domestic cats: the CABSS score |
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| Affiliation: | 1. Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa;2. Anaesthesia and Critical Care Services, Valley Farm Animal Hospital, Pretoria, South Africa;3. Brain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa;4. Optivet Referrals, Havant, Hampshire, United Kingdom;5. Clinical Sciences Department, Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis;1. Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan;2. Veterinary Medicine Teaching Hospital, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan;1. Faculty of Veterinary Medicine, Université de Montréal, Saint-Hyacinthe, QC, Canada;2. Groupe de recherché en pharmacologie animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada;3. Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada;1. The University Veterinary Teaching Hospital, The School of Veterinary Science, The University of Sydney, New South Wales, Australia;2. Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, Murcia, Spain;3. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Anestesiología y Algiología, Buenos Aires, Argentina;1. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA;2. Veterinary Medical Center, College of Veterinary Medicine, University of Minnesota, St Paul, MN, USA |
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| Abstract: | ObjectiveTo determine whether physiological, haematological, biochemical or electrolyte variables can predict severe haemorrhage in cats.Study designRandomized crossover study whereby each cat underwent mild and severe haemorrhage, with a 2 month period between events.AnimalsA group of six domestic cats aged 21 ± 1 months and weighing 4.9 ± 1.2 kg, mean ± standard deviation.MethodsCats were anaesthetized (buprenorphine, alfaxalone, isoflurane in oxygen at a fixed end-tidal concentration of 1.7%) before the haemorrhage event. In total, 34 variables were measured twice (prehaemorrhage and posthaemorrhage). The difference and percent change for each variable were compared between haemorrhage events (paired t test). Significant variables were placed into 13 different ratios (posthaemorrhage value of one variable divided by a posthaemorrhage value of a second variable) and compared (paired t test), and Cohen’s d (d) was calculated. Receiver operating characteristic curves were plotted and cut-off values for weak, moderate and strong indicators of severe haemorrhage were obtained.ResultsThe blood loss was 4.5 ± 1.1 mL kg–1 and 26.8 ± 5.5 mL kg–1 for mild and severe haemorrhage events, respectively. The most significant variables with large effect sizes were heart rate (HR), systolic arterial blood pressure (SAP), end-tidal carbon dioxide (Pe′CO2), serum albumin, haematocrit and actual bicarbonate ion concentration [HCO3−(act)]. The most robust ratios were: 1) shock index (d = –2.8; HR:SAP); 2) HR:Pe′CO2 (d = –2.9); 3) serum albumin: haematocrit (d = 1.5); and 4) HR:HCO3−(act) (d = –1.6). These ratios were included in the final proposed Cat Acute Bleeding Scoring System (CABSS).Conclusionsand clinical relevance Cats subjected to mild and severe haemorrhage demonstrated statistically and clinically relevant changes whereby four ratios could be created to make up the CABSS. The ratios detected and quantified the presence of severe haemorrhage in anaesthetized cats. |
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| Keywords: | cat haemorrhage intraoperative haemorrhage scoring system |
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