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New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.
Authors:Bolin Hou  Sushi Liu  Ruiyun Huo  Yueqian Li  Jinwei Ren  Wenzhao Wang  Tao Wei  Xuejun Jiang  Wenbing Yin  Hongwei Liu  Ling Liu  Erwei Li
Affiliation:1.State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; (B.H.); (S.L.); (R.H.); (Y.L.); (J.R.); (W.W.); (X.J.); (W.Y.); (H.L.);2.Beijing Key Laboratory of Bioactive Substance and Functional Foods, Beijing Union University, Beijing 100191, China;3.Institutional Center for Shared Technologies and Facilities, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Abstract:
Two new diterpenoids, hypoxyterpoids A (1) and B (2), and four new isocoumarin derivatives, hypoxymarins A–D (4–7), together, with seven known metabolites (3 and 8–13) were obtained from the crude extract of the mangrove-derived fungus Hypoxylon sp. The structures of the new compounds were elucidated on the basis of 1- and 2-dimensional (1D/2D) nuclear magnetic resonance (NMR) spectroscopic and mass spectrometric analysis. The absolute configurations of compounds 1, 2, 4, 5, and 7 were determined by comparison of experimental and calculated electronic circular dichroism (ECD) spectra, and the absolute configurations of C-4′ in 6 and C-9 in 7 were determined by [Rh2(OCOCF3)4]-induced ECD spectra. Compound 1 showed moderate α-glucosidase inhibitory activities with IC50 values of 741.5 ± 2.83 μM. Compounds 6 and 11 exhibited DPPH scavenging activities with IC50 values of 15.36 ± 0.24 and 3.69 ± 0.07 μM, respectively.
Keywords:mangrove-derived fungus   secondary metabolites   absolute configurations   bioactivity
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