Pharmacokinetics and Dosage Regimen of Enrofloxacin in Buffalo Bulls after Intramuscular Administration |
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| Authors: | Verma HK Pangawkar GR Chaudhary RK Srivastava AK |
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| Institution: | (1) Department of Veterinary and A.H. Extension, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India;(2) Department of Animal Reproduction, Gynaecology and Obstetrics, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India;(3) Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana, 141004, India |
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| Abstract: | The disposition kinetics and dosage regimen of enrofloxacin were investigated in breeding buffalo bulls following a single intramuscular administration of 5 mg/kg. The absorption half-life, half-life of the terminal phase, apparent volume of distribution and total body clearance were 0.262±0.099 h, 1.97±0.23 h, 0.61±0.13 L/kg and 210.2±18.6 ml/(kg.h), respectively. Therapeutic plasma levels ( 1  g/ml) were maintained for up to 6 h. A satisfactory intramuscular dosage regimen for enrofloxacin in buffalo bulls would be 8.5 mg/kg followed by 8.0 mg/kg at 8 h intervals. |
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| Keywords: | antibiotics buffalo disposition dosage enrofloxacin pharmacokinetics |
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