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The Effect of Intravenous Administration of Web 2086 on PAF-Induced Platelet Aggregation in Healthy Friesian Calves |
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| Authors: | Da Silva M Bastos Gustin P Herion F Raskinet R David J-L Gougnard T Plomteux G Desmecht D Lekeux P |
| Institution: | (1) Laboratory for Functional Investigation, Department of Physiology, Bât. B42, University of Liege, Sart Tilman, B-4000 Liege, Belgium;(2) Laboratory of Pharmacology and Toxicology, Bât. B41, Faculty of Veterinary Medicine, University of Liege, Sart Tilman, B-4000 Liege, Belgium;(3) Thrombosis-Hemostasis Unit, C.H.U., B35, University of Liege, Sart Tilman, B-4000 Liege, Belgium;(4) Laboratory of Clinical Toxicology, C.H.U., Bât. 35, University of Liege, Sart Tilman, B-4000 Liege, Belgium |
| Abstract: | The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. |
| Keywords: | aggregation cattle chromatography platelet platelet-activating factor platelet-rich plasma thienotriazolodiazepine |
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