| 6个鸡种腺苷单磷酸脱氨酶1基因克隆及序列分析 |
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| 引用本文： | 张学余,季从亮,陈国宏,黄兆明,苏一军,沈晓鹏.6个鸡种腺苷单磷酸脱氨酶1基因克隆及序列分析[J].云南农业大学学报,2004,19(2):224-226. |
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| 作者姓名： | 张学余 季从亮 陈国宏 黄兆明 苏一军 沈晓鹏 |
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| 作者单位： | [1]中国农业科学院家禽研究所，江苏扬州225003 [2]扬州大学畜牧兽医学院，江苏扬州225009 |
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| 基金项目： | 国家863计划(2001AA243082)，江苏省科技计划(BG2001319，BJ200043) |
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| 摘 要： | 以肌苷酸合成代谢过程中主要的催化酶之一的鸡腺苷单磷酸脱氨酶1（adenosine monophosphate deaminase 1,AMPD1）基因作为候选基因,分析了其在6个鸡种中的序列多样性,发现在525 bp的片段中共存在10个多态位点,其中120位的A→G,355位的A→G的碱基变化仅在泰和乌骨鸡、北京油鸡、茶花鸡肌苷酸含量较高的鸡种中出现,推测这两个位点与肌苷酸含量密切相关。另外该基因与体重也可能具有相关性。
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| 关 键 词： | 鸡种 肌苷酸 腺苷单磷酸脱氨酶1基因 |
| 文章编号： | 1004-390X(2004)02-0224-03 |
| 收稿时间： | 2003-12-1 |
Cloning and Analysis of Sequence of Adenosine Monophosphate Deaminase 1 Gene in 6 Chicken Breeds |
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| ZHANG Xue-yu,JI Cong-liang,CHEN Guo-hong,HUANG Zhao-ming,SU yi-jun,SHEN Xiao-pen.Cloning and Analysis of Sequence of Adenosine Monophosphate Deaminase 1 Gene in 6 Chicken Breeds[J].Journal of Yunnan Agricultural University,2004,19(2):224-226. |
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| Authors: | ZHANG Xue-yu JI Cong-liang CHEN Guo-hong HUANG Zhao-ming SU yi-jun SHEN Xiao-pen |
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| Institution: | ZHANG Xue-yu~1,JI Cong-liang~2,CHEN Guo-hong~2,HUANG Zhao-ming~1,SU yi-jun~1,SHEN Xiao-pen~1 |
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| Abstract: | Adenosine monophosphate deaminase catalyzes the deaminatin of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. In this study, part of the sequence of AMPD1 gene was cloned and analyzed. 10 polymorphic sites were found in 6 chicken breeds. For the two mutations of A120G and A355G only existed in Taihe Silkies and Beijing fatty chickens which are famous for its high IMP content in muscle, we concluded that there may be a relationship between these two sites and IMP content in chickens. There may be an association between the AMPD1 gene and body weight. |
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| Keywords: | chicken breeds inosinic acid AMPD1 gene |
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