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Differences in IgG1 and IgG2 responses of cattle infected with Coxiella burnetii and following vaccination
Authors:N Schmeer  H Krauss  W Lohrbach  D Wiegand
Affiliation:1. Institut für Hygiene und Infektionskrankheiten der Tiere, Justus-Liebig-Universität Giessen, D-6300 Giessen, Frankfurter Str. 89, West Germany;2. Staatliche Veterinäruntersuchungsämter Frankfurt West Germany;3. Staatliche Veterinäruntersuchungsämter Giessen, West Germany;1. Department of Immunology, Pathophysiology and Veterinary Preventive Medicine, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland;2. Teagasc, Animal and Bioscience Research Department, Moorepark Research Centre, Fermoy, Ireland;3. Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland;4. Department of Pathology, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland;5. Department of Virology, National Veterinary Research Institute, Pulawy, Poland;1. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Inmunología, Av. Chorroarín 280, C1427CWO, Buenos Aires, Argentina;2. Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Instituto de Investigación y Tecnología en Reproducción Animal (INITRA), Av. Chorroarín 280, C1427CWO, Buenos Aires, Argentina;3. Instituto Nacional de Tecnología Agropecuaria (INTA), Estación Experimental Agropecuaria Balcarce, Laboratorio de Bacteriología, Ruta 226, Km 73.5, Provincia de Buenos Aires, Balcarce B7620BEN, Argentina;4. Universidad Nacional de Mar del Plata, Facultad de Ciencias Agrarias, Departamento de Producción Animal, Mar del Plata, Ruta 226, Km 73.5, Provincia de Buenos Aires, Balcarce B7620BEN, Argentina;1. Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G2W1, Canada;2. Veterinary Science and Policy, Ontario Ministry of Agriculture, Food and Rural Affairs, 6484 Wellington Rd 7, Unit 10, Elora, Ontario N0B 1S0, Canada
Abstract:
Vaccination of 115 cattle with a formalin-inactivated Coxiella burnetii (Phase II) vaccine selectively induced a highly significant IgG2 response detectable by enzyme-linked immunosorbent assay. High IgG2 and negative or cut off IgG1 levels could be detected in uninfected cattle, whereas significant IgG1 but lower IgG2 levels were associated with C. burnetii infections.
Keywords:
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