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Genetically determined sex-reversal in 46,XY humans |
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| Authors: | J German J L Simpson R S Chaganti R L Summitt L B Reid I R Merkatz |
| Abstract: | Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women. |
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