Acute Reactions in Dogs Treated with Doxorubicin: Increased Frequency with the Use of a Generic Formulation

During a 4-month period, 34 dogs with tumors received a total of 60 doses of a single generic formulation of doxorubicin; 13 acute drug reactions were observed in these 34 dogs, and no acute reactions were observed after replacing the product with the proprietary brand. These reactions were characterized by one or more of the following signs: pruritus; head-shaking; urticaria; erythema of the pinnal, axillary, or inguinal regions; vocalization; vomiting; hyperemic or pale mucous membranes; high heart rate; and high respiratory rate. We propose that a component unique to generic doxorubicin was responsible for the unusually high number of acute drug reactions observed.     

Anaphylaxis to Ophthalmic Medication in a Cat

There is an increasing incidence of anaphylactic reactions in cats due to the administration of ophthalmic bacitracin, neomycin, polymyxin medications. Most of the reported cases have been fatal. This is the report of a cat that survived the initial episode only to develop renal failure and cardiomyopathy. This lead to euthanasia seven days later. Dr. Kathryn Meyer of the U.S. Pharmacopeia and Dr. Signe Plunkett of the Emergency Animal Clinic in Phoenix are conducting an ongoing study, and they are interested in the reports of any additional cases.