制动防抱死系统在汽车上的应用

在文中通过研究汽车制动时的受力情况、路面附着特性、制动防抱死系统的控制方式、组成和工作情况，得出了使车轮滑动率保持在20％的最佳状态可提高汽车的制动效能，缩短制动距离。并使汽车具有较好的转向和抵抗侧向力的作用，提高汽车制动时的方向稳定性的结论。     

Action of Clathrodin and Analogues on Voltage-Gated Sodium Channels

Clathrodin is a marine alkaloid and believed to be a modulator of voltage-gated sodium (Na_V ) channels. Since there is an urgent need for small molecule Na_V channel ligands as novel therapeutics, clathrodin could represent an interesting lead compound. Therefore, clathrodin was reinvestigated for its potency and Na_V channel subtype selectivity. Clathrodin and its synthetic analogues were subjected to screening on a broad range of Na_V channel isoforms, both in voltage clamp and patch clamp conditions. Even though clathrodin was not found to exert any activity, some analogues were capable of modulating the Na_V channels, hereby validating the pyrrole-2-aminoimidazole alkaloid structure as a core structure for future small molecule-based Na_V channel modulators.     

一种改进的载波抑制调制光毫米波信号的产生方案

为了克服光纤无线(ROF)系统中色散对光载波抑制(OCS)调制光毫米波信号传输的影响,提出一种改进的OCS调制方案。使用双驱动马赫-曾德尔调制器(MZM),通过调整两路输入射频信号相位、基带信号增益和直流偏置电压将2.5Gbit/s数据信号仅调制到(OCS)信号的一个边带上传输。理论分析表明,与传统OCS调制光毫米波信号产生方案相比,本文方案解决了色度色散引起的码元走离问题,大大增加了传输距离。仿真实验结果表明,经过110km光纤传输后信号的眼图仍然十分清晰,在BER=10-10条件下,信号经过20、40和60km光纤传输后的功率代价分别为0.78、1.7和1.9dB。     

Chalinulasterol, a chlorinated steroid disulfate from the Caribbean sponge Chalinula molitba. Evaluation of its role as PXR receptor modulator

Chalinulasterol (1) a new chlorinated sterol disulfate was isolated from the Caribbean sponge Chalinula molitba. Its structure was elucidated using mass spectrometry and NMR experiments. The possible role of chalinulasterol as modulator of the PXR nuclear receptor was investigated but, in spite of the close structural relationship with the PXR agonist solomonsterol A (2), it showed no activity. The structural requirements for the PXR nuclear receptor activity were discussed.     

微生态制剂中抑菌物质的分析

本文以一种市售微生态制剂为试材,对其产生的抑菌活性物质的生化性质做了研究,发现该抑菌物质显示活性的ｐＨ范围为４．０～６．０,ｐＨ值变化对其活性影响较大,ｐＨ值为７．０时活性全部消失;该活性物质对热不敏感,１２１℃处理３０ｍｉｎ后,其活性无明显变化;紫外光照射也不能使它失活;随发酵时间的延长,发酵液中的抑菌活性物质逐渐增加。根据其生化性质可以判断该抑菌物质是一种分子量较小,结构简单的多肽,具有广谱抑     

THE APPLICATION OF ELECTRO-OPTIC EFFECT TO HOLOGRAPHY

This paper uses LN-Class LiNbO3 crystal to make a laser beamsplitter and a phase modulator, In the Paper devices and results have been given, and deviation factor between experiment and theory have been analyzed. This device is over a wide range of adjusting. Its reapeatability is good, and the devive is simple andconvenient.     

基于∑-△调制技术的信号发生器设计

提出了一种新的采用ΣΔ调制和无损离散积分振荡器来产生片内模拟信号的方法.研究了电路的实现原理和噪声传递函数零点优化设计方法,运用无乘法器的梯型滤波器结构和ΣΔ调制技术避免了多位高精度乘法运算和多位D/A数模转换器硬件成本高的缺点.除一个比较器外,整个电路全部由标准CMOS工艺来实现集成,硬件成本非常低,非常适用基于可测性混合集成电路的设计.通过一个6阶实例和仿真的结果表示:6阶的信号发生器具有120 dB衰减的动态带宽.     

微生态调节剂对猪粪堆肥过程中微生物群落的影响

利用微生物可培养方法研究了猪粪堆肥过程中添加堆肥微生态调节剂和不添加堆肥微生态调节剂(自然堆肥) 对猪粪堆肥微生物群落的影响,研究发现接种ZZMZ堆肥微生态调节剂可以使猪粪便堆肥细菌数量提高4.53%,放线菌数量提高6.37%,微生物总数提高4.22%,而真菌数量则降低了65.93%。说明ZZMZ堆肥微生态制剂在堆肥前期能够激发微生物数量,从而加快堆肥进程,缩短堆肥周期     

Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo- and Rheumatoid Arthritis

Arthritis is a widespread inflammatory disease associated with progressive articular surface degradation, ongoing pain, and hyperalgesia causing the development of functional limitations and disability. TRPV1 channel is one of the high-potential targets for the treatment of inflammatory diseases. Polypeptide APHC3 from sea anemone Heteractis crispa is a mode-selective TRPV1 antagonist that causes mild hypothermia and shows significant anti-inflammatory and analgesic activity in different models of pain. We evaluated the anti-inflammatory properties of APHC3 in models of monosodium iodoacetate (MIA)-induced osteoarthritis and complete Freund’s adjuvant (CFA)-induced rheumatoid monoarthritis in comparison with commonly used non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, and meloxicam. Subcutaneous administration of APHC3 (0.1 mg/kg) significantly reversed joint swelling, disability, grip strength impairment, and thermal and mechanical hypersensitivity. The effect of APHC3 was equal to or better than that of reference NSAIDs. Protracted treatment with APHC3 decreased IL-1b concentration in synovial fluid, reduced inflammatory changes in joints, and prevented the progression of cartilage degradation. Therefore, polypeptide APHC3 has the potential to be an analgesic and anti-inflammatory substance for the alleviation of arthritis symptoms.     

微生态调节剂对猪粪堆肥过程中微生物生理群的影响

利用微生物的可培养方法研究了猪粪堆肥过程中添加堆肥微生态调节剂和不添加堆肥微生态调节剂(自然堆肥) 微生物生理群的变化情况,研究发现接种ZZMZ堆肥微生态调节剂可以使好气性纤维素分解细菌数量提高22.52％,氨化细菌数量提高14.95％,氨氧化细菌数量提高15.87％,亚硝酸氧化细菌数量提高38.46％,嫌气性纤维素分解细菌数量降低30.56％,反硝化细菌数量降低39.92％。