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排序方式: 共有175条查询结果,搜索用时 31 毫秒
1.
J O Slocombe 《Veterinary parasitology》1985,18(2):139-153
This review summarizes information on the clinical signs, gross and microscopic lesions associated with nematode and cestode infections and discusses the development of these conditions in the equine host. 相似文献
2.
The development and pathological effects of Strongylus equinus were studied in 17 pony foals and one horse foal raised in isolation and examined at necropsy from seven days to 40 wk postinfection (PI). Following inoculation of 15000 +/- 6% or 16000 +/- 6% infective larvae by stomach tube foals were monitored for clinical signs and selected blood changes. Larvae penetrated the wall of the ileum, cecum and colon. The molt to the fourth stage occurred mostly in the wall of the ventral colon before 2 wk PI and larvae attained the liver mainly via the peritoneal cavity as early as eight days PI and persisted in the liver until 17 wk PI. Following active migration within the liver, invasion of the pancreas was accomplished at least by 7 wk PI with maximum numbers at 17 wk. The fourth molt occurred about 15 wk PI and preadults were present in the wall of the ventral colon at 30 wk PI and in the lumen of the colon at 40 wk. Strongylus equinus tends to wander retroperitoneally to the flanks, perirenal fat, diaphragm, omentum and occasionally to the lungs. Between 1 and 4 wk PI small raised hemorrhagic areas were present on the serosa of the ileum and colon. Small white foci on the surface of the liver at 1 wk PI were followed by tortuous tracks 3 wk later. Pathological changes in the pancreas were evident at three months PI and more severe by four months. Granulomas containing larvae were common in the flanks, diaphragm, omentum and occasionally beneath the pleura of the lungs. Clinical signs were correlated with invasion of the pancreas, the fourth molt, maximum globulin values and high eosinophil counts. 相似文献
3.
Michael Lynch Helen McCracken Ronald Slocombe 《Journal of zoo and wildlife medicine》2002,33(3):263-271
Three adult red pandas (Ailurus fulgens) developed multiple periarticular exostoses in their elbow joints. Two of these animals also had extensive periosteal new bone formation and osteosclerosis of the ulnae and radii and mild periosteal new bone deposition on the femurs. One animal also showed extensive hyperostosis of the cranium and mandibles. Dietary concentrations of calcium and phosphorus were estimated to be adequate, but dietary vitamin A and D appeared excessive when compared with recommended levels for this species. Serum vitamin A concentrations were not elevated in the two most severely affected animals, but their liver vitamin A content was higher than what is considered normal for most domestic animal species. Serum 25-hydroxy vitamin D concentrations were within normal ranges for domestic species. A definitive diagnosis for the cause of the lesions was not established, but hypervitaminosis A was suspected. 相似文献
4.
Pulmonary responses to intratracheal challenge exposure with Pasteurella haemolytica, with or without Escherichia coli-derived endotoxin, E coli endotoxin alone, or saline solution were compared in anesthetized, mechanically ventilated neonatal calves. Baseline values for dynamic compliance, total pulmonary resistance, functional residual capacity, arterial blood gas tensions, hemogram, leukogram, and systemic and pulmonary arterial pressures were recorded for each calf. After baseline data were obtained, calves were challenge exposed with logarithmic-growth phase P haemolytica organisms with or without E coli endotoxin, E coli endotoxin alone, or saline solution (0.9% NaCl). Physiologic data were obtained immediately after challenge exposure and at various intervals over the next 6 hours. Calves challenge exposed with P haemolytica alone developed sever hypoxemia, had increased alveolar-arterial oxygen difference and threefold increases in total pulmonary resistance, became hypercarbic, had decreased functional residual capacity, and developed systemic hypotension without change in pulmonary arterial pressure. At necropsy, these calves had extensive multifocal areas of necrohemorrhagic and purulent pneumonia. Ratio of extravascular lung water to lung dry weight was not significantly increased in lung specimens obtained from calves challenge exposed with P haemolytica, but ratio of lung wet weight to dry weight was increased, indicating that increased lung wet weight was attributable largely to increased solids and not to fluid alone. (Extravascular lung water measurement excludes fluid from the vascular compartment.) Intratracheal challenge exposure with endotoxin failed to alter lung function and caused minor changes in lung structure consisting of focal areas of hemorrhage and edema.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
J L Duncan J H Arundel J H Drudge A Malczewski J O Slocombe 《Veterinary parasitology》1988,30(1):57-72
These guidelines have been designed to assist in the planning, operation and interpretation of studies which would serve to assess the efficacy of drugs against internal parasites of horses. Although the term anthelmintic is used in the title and text, these guidelines include studies on drug efficacy against larvae of horse bot flies, Gasterophilus spp, which are non-helminth parasites commonly occurring in the stomach of horses. The advantages, disadvantages and application of critical and controlled tests are presented. Information is also provided on selection of animals, housing, feed, dose titration, confirmatory and clinical trials, record keeping and necropsy procedures. These guidelines should assist both investigators and registration authorities in the evaluation of compounds using comparable and standard procedures with the minimum number of animals. 相似文献
6.
J A Stick R F Slocombe F J Derksen E A Scott 《American journal of veterinary research》1983,44(11):2123-2132
Esophageal healing was studied in 12 ponies after cervical esophagotomy. The esophagus was sutured, feed and water were withheld for 48 hours, and then all ponies were permitted to eat. In group I (n = 6), a longitudinal esophagotomy was made. In group II (n = 6), a rotational esophagotomy was made with the mucosal incision 180 degrees away from the incision in the esophageal muscle. Three ponies in each group were fed a soft diet ad libitum for 9 days, and then were allowed access to hay and grain. The remaining ponies were fed hay and grain. The esophagotomies of all hay-fed ponies dehisced and healed by second intention, whereas esophagotomies healed by first intention in the ponies given a soft diet. Endoscopic and radiographic examinations indicated that the progression of healing in the present study was a function of diet (form of food), rather than surgical technique. The cross-sectional width of the muscularis externa at the incision site was 39.6% greater in mash-fed ponies than in hay-fed ponies. Based on density-dependent image analysis, average elastin content and reticulin fiber of the submucosa and muscularis externa at the incision were not influenced by the form of feed or surgical technique, although elastin fiber regeneration did not occur at the site of the incision. 相似文献
7.
Efficiency and Sensitivity of Techniques for Recovering Nematode Eggs from Bovine Feces 总被引:1,自引:1,他引:0 下载免费PDF全文
Haemonchus contortus eggs were extracted from sheep feces and known numbers were added to helminthologically sterile bovine feces to provide samples with seven, 30 and 60 eggs per gram (epg). At 60 epg, dilution techniques (modified Cornell-McMaster and modified McMaster) tended to overestimate the number of eggs and more eggs were recovered (mean of 121 and 88% respectively) with these techniques than with centrifugal concentration procedures (modified Cornell—63% and Wisconsin— 69%). At 30 epg, all techniques were comparable (modified Cornell-McMaster 67%, modified McMaster 63%, modified Cornell and Wisconsin 64%). At 7 epg, the Wisconsin (61%), modified Cornell (60%) and Cornell-McMaster (94%) techniques were comparable and better than the modified McMaster technique (16%). At all levels of epg, the modified Cornell and Wisconsin techniques recovered eggs from 100% of the samples. The Cornell-McMaster and modified McMaster techniques recovered eggs from 90 and 100% of samples at 60 epg; 40 and 100% at 30 epg; and 21 and 11% at 7 epg. With a gravitational concentration procedure, the Standard Vial, no more than 16% of the eggs at any level of epg were recovered and at 7 epg eggs were recovered from only one-half of the samples. Five gravitational concentration techniques were assessed over 66 to 490 epg. The Ovassay, Fecalyzer and modified Standard Vial techniques were comparable in efficiency (28%, 25% and 24% respectively), but the Standard Vial technique was less efficient (11%).
Introduced into diagnostic parasitology was the concept of predictive values which is the proportion of samples that a technique correctly identifies as being negative for parasite eggs. At 7 epg this was calculated to be zero for the modified Cornell-McMaster, modified McMaster and Standard Vial techniques and 100 for the Wisconsin and modified Cornell techniques.
相似文献8.
The effects of 3 feeding techniques on healing of a cervical esophageal mucosal resection and anastomosis were investigated in 16 horses. Horses were fed a moistened pelleted diet 1 of 3 ways: 1) per os (n = 5), 2) by nasogastric (n = 5) or 3) by esophagostomy tube (n = 6) until the 14th postoperative day. The pelleted diet was then fed orally in all horses until euthanasia on the 60th postoperative day. Immediate postoperative feeding per os was unsatisfactory, as only 2 of 5 horses survived in this group. Endoscopic evaluation revealed that mucosal dehiscence of varying degrees occurred, with subsequent stricture formation in all horses. Although the incidence of some complications (fistula, sinus tract and traction diverticulum) was higher in the nasogastric tube-fed horses, 2 of 6 horses in the esophagostomy tube-fed group did not survive to the end of the study. There was more cervical phlegmon in the esophagostomy tube-fed group, and this resulted in increased periesophageal fibrosis on histopathologic examination. Radiographic measurements showed that esophageal lumen diameter increased predominantly between 30 and 45 days postoperatively. The mucosal healing time was significantly faster (p = 0.05) in the esophagostomy tube-fed group. 相似文献
9.
Boden LA Anderson GA Charles JA Morgan KL Morton JM Parkin TD Clarke AF Slocombe RF 《Equine veterinary journal》2007,39(5):422-428
REASONS FOR PERFORMING STUDY: The risk of fatality is greater in jump than in flat racing in Victoria, Australia. This is the first study to identify risk factors specific to jump starts in Victoria. OBJECTIVE: To identify risk factors for fatality of Thoroughbred racehorses in jump starts on all racecourses in Victoria, Australia between 1989 and 2004. METHODS: Fatalities comprised all horses that died during or immediately after a jump (hurdle or steeplechase) race or official jump trial and all horses that were subjected to euthanasia within 24 h of an event in which an injury was sustained. The retrospective study involved 191 case starts and 2324 control starts. Univariable and multivariable backward stepwise logistic regression was used to identify risk factors for fatality at any one start. A multiple level model was used with racecourse included as a random effect. RESULTS: In the final multivariable model, the duration of the racing career of the horse, the number of flat, hurdle and steeple starts accumulated in the 60 days prior to the case or control start, the number of flat and jump starts accumulated over the racing career, if the horse had had a start between 1 and 14 days prior to the case or control start, the type of jump race (hurdle or steeple), the calendar year of the start and the location of the racecourse were associated with fatality. CONCLUSIONS: The findings highlight the need to investigate further the differences between hurdle and steeplechase events and the adverse effect of prolonged prior flat racing careers on the risk of fatality in jump starts. POTENTIAL RELEVANCE: This is the first study to examine risk factors for fatality in jump starts in Victoria. The results should shape the development of interventions to reduce the risk in jump starts in the future. 相似文献
10.