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Zoledronate is a bisphosphonate frequently used for the treatment of hypercalcaemia of malignancy and tumour-associated bone pain in dogs, however, there is a paucity of information regarding its use in veterinary medicine. The aim of this retrospective study was to report the tolerability of zoledronate in the palliative treatment of cancer-bearing dogs and secondarily to to assess the efficacy of zoledronate for the treatment of hypercalcaemia of malignancy. Thirty-seven dogs (22 with tumour-associated bone pain and 15 with hypercalcaemia of malignancy) that received 114 zoledronate infusions were included. Tolerability was assessed by the absence of post-zoledronate hypocalcaemia or other adverse events as defined by Veterinary Cooperative Oncology Group-Common Terminology Criteria for Adverse Events criteria. Efficacy was assessed by comparison of available ionized calcium levels before and after zoledronate administration in hypercalcaemic dogs. In 79% of zoledronate infusions, no adverse events were reported. The majority of adverse events which occurred in the other 21% of infusions could be attributed to concurrent chemotherapy or the underlying neoplastic disease. There was a small but significant increase in creatinine following treatment with zoledronate, however, none of the dogs developed clinically significant renal disease. In eight hypercalcaemic dogs with available ionized calcium following zoledronate administration, ionized calcium decreased rapidly within 7 days following treatment with zoledronate. Zoledronate is well-tolerated with few recorded adverse events, however, monitoring of serum creatinine is advised. Zoledronate seems to be effective in the treatment of hypercalcaemia of malignancy. 相似文献
3.
Ján BURKU? Martina KA?MAROVá Janka KUBANDOVá Natália KOKO?OVá Kamila FABIANOVá Du?an FABIAN Juraj KOPPEL ?tefan ?IKO? 《The Journal of reproduction and development》2015,61(4):325-331
We found retardation of preimplantation embryo growth after exposure to maternal restraint stress during the preimplantation period in our previous study. In the present study, we evaluated the impact of preimplantation maternal restraint stress on the distribution of inner cell mass (ICM) and trophectoderm (TE) cells in mouse blastocysts, and its possible effect on physiological development of offspring. We exposed spontaneously ovulating female mice to restraint stress for 30 min three times a day during the preimplantation period, and this treatment caused a significant increase in blood serum corticosterone concentration. Microscopic evaluation of embryos showed that restraint stress significantly decreased cell counts per blastocyst. Comparing the effect of restraint stress on the two blastocyst cell lineages, we found that the reduction in TE cells was more substantial than the reduction in ICM cells, which resulted in an increased ICM/TE ratio in blastocysts isolated
from stressed dams compared with controls. Restraint stress reduced the number of implantation sites in uteri, significantly delayed eye opening in delivered mice, and altered their behavior in terms of two parameters (scratching on the base of an open field test apparatus, time spent in central zone) as well. Moreover, prenatally stressed offspring had significantly lower body weights and in 5-week old females delivered from stressed dams, fat deposits were significantly lower. Our results indicate that exposure to stress during very early pregnancy can have a negative impact on embryonic development with consequences reaching into postnatal life. 相似文献
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Otto Pesta 《Journal of pest science》1956,29(1):5-6
Ohne Zusammenfassung 相似文献
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Hans Jürgen Bestmann Beate Classen Uwe Kobold Otto Vostrowsky Fred Klingaup 《Journal of pest science》1987,60(2):31-34
The essential oil ofChrysanthemum balsamita L. revealed insecticidal properties when tested againstM. dirhodum aphids. The insecticidal activity was attributed to the presence of pyrethrine I in the oil. By an appropriate testing procedure, the dependence of the activity upon the time of harvesting of the plants was determined. Furthermore, the insecticidal effect of the oil was compared with that of a commercially available pyrethrum preparation. 相似文献
7.
Prof. Dr. D. Otto 《Journal of pest science》1997,70(2):30-33
The female sex pheromone ofL. decemlineata is an aphrodisiacum, switching on mating behaviour in contacting males. A biotest is described to estimate quantitatively the exciting power of a subject (female, isolated elytrae, glass dummy coated with extract) to males. The pheromone is present only in fertile females, also in freshly killed ones. It can be extracted by organic solvents. A dummy imitating a beetle's abdomen and contaminated with the residue of a female s wash solution is exciting to males too. Suitable solvents are ethylalcohol, acetonet, hexane. By this, the pheromone of 0,1 female is detectable. The residue can be taken up again with the same or an other solvent. The solution can be stored at ?18°C without significant losses, but at temperatures>+5°C their efficacy diminishes during 2 weeks. The exciting efficacy of the dry residue desreases to about 50% during nearly 4 weeks (at+22°C) or 9 weeks (at+5°C). The pheromone resists heating to about+160°C and is destroyed at higher temperatures. 相似文献
8.
通过在三种杨树无性系,I-214(Populus×euranericanacv.I-214)(ltalica)、中东杨(P.berolinensis)(Berolinensis)和群众杨(P.popularis35-44)(Popularis)一年生盆栽插条苗的木质部导入ABA和细胞分裂素,研究了这两类激素在气孔调控中的作用。尽管不同无性系的气孔在对ABA的敏感性上存在显著差异,但ABA仍可导致气孔的关闭,然而在蒸腾流中的细胞分裂素(与ABA共导入或分别导入)可以明显地抑制ABA的作用。并且玉米素还能推迟土壤干旱所诱导的气孔关闭,在水分胁迫条件下,内源细胞分裂素浓度下降而同时ABA上升.据此提出了复合胁迫信号的概念,即在根冠通讯中,是ABA和细胞分裂素共同调控气孔的运动。另外还研究了玉米素、激动素、6-BA等不同细胞分裂素与ABA的相互作用,结果发现6-BA与玉米素和激动素的作用相反,它不能抑制ABA的作用,反而促进其对气孔的关闭 相似文献
9.
Ohne Zusammenfassung 相似文献
10.
Otto Eichhorn 《Journal of pest science》1958,31(8):124-124
Ohne Zusammenfassung 相似文献