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Satoshi KAMBAYASHI Masaya IGASE Kosuke KOBAYASHI Ayana KIMURA Takako SHIMOKAWA MIYAMA Kenji BABA Shunsuke NOGUCHI Takuya MIZUNO Masaru OKUDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(11):1405-1412
Hypoxic conditions in various cancers are believed to relate with their
malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major
regulator of the response to low oxygen. In this study, we examined HIF-1α expression in
canine lymphoma using cell lines and clinical samples and found that these cells expressed
HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol,
suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using
NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor.
Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine
lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine
lymphoma. 相似文献
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Noborio Kosuke Ito Yuki He Hailong Li Min Kojima Yuki Hara Hirofumi Mizoguchi Masaru 《Paddy and Water Environment》2018,16(1):81-87
Paddy and Water Environment - Hydraulic properties of soil play important roles in water and temperature regimes. Measuring hydraulic properties has been studied for decades in the laboratory and... 相似文献
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Kosuke Izumitsu Syunichi Kimura Hajime Kobayashi Atsushi Morita Yoshimoto Saitoh Chihiro Tanaka 《Journal of General Plant Pathology》2010,76(4):254-260
Hydrophobins are small secreted proteins unique to filamentous fungi. In this study, we cloned and characterized the class
I hydrophobin gene BcHpb1 in the necrotrophic pathogen Botrytis cinerea. The BcHpb1 protein consisted of 117 amino acids. Similar to class I hydrophobins from other fungi, BcHpb1 contains eight
conserved cysteine residues. The hydropathy plot of the BcHpb1 amino acid sequence was characteristic of a class I hydrophobin.
These results indicated that the BcHpb1 gene encodes a class I hydrophobin. Vegetative growth of ΔBcHpb1 strains, null mutants of BcHpb1, was similar to that of the wild-type strain as were the conidiophores, conidia, appressoria and virulence on host plants.
However, adherence of ΔBcHpb1 strains to hydrophobic surfaces was greatly reduced, implying that BcHpb1 is important for the hydrophobicity of conidia
and that BcHpb1 may be required to adhere to plant surfaces under certain environmental conditions. 相似文献
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Ground-dwelling beetle community in beech forests of Sado Island,Japan: comparison with the mainland
Island ecosystems differ from mainland ecosystems in their long-term isolation. On Sado Island, Japan, cattle grazing in the
past gradually changed forests into grasslands, thereby altering the diversity of indigenous insects. We compared ground-dwelling
beetle diversity on Sado Island to that on the nearby mainland. Contrary to previous reports, the island isolation effect
resulted in lower γ and β diversity than on the mainland, because of the low species richness of beetles with low dispersal
abilities. Few flightless beetles could invade Sado Island, even when the beech forests on the island were relatively adjacent
to those on the mainland. Such a history of ecosystem formation could be the general pattern for continental-island mountain
forests that were never connected to those of the mainland. We did not observe low α diversity of ground-dwelling beetles,
suggesting that the cattle grazing history of the island has not changed environmental conditions for ground-dwelling beetles
enough to reduce their diversity. In addition, cattle grazing increases the abundance of merdivorous insects by increasing
the abundance of their food resource.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
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At 114 ranches in the Hidaka District of Hokkaido, a total of 1,118 Thoroughbred foals
that were born from January to June 2003 were examined at different times from May to
September of the same year to ascertain the occurrence of clubfoot. Clubfoot was seen in a
total of 179 foals (16%) at 89 ranches (78%). Also, 124 of the 179 foals (69.3%) had
clubfoot of grade II or higher, and it was found that grade I was likely to be overlooked
or rapidly advance. In the present study, the occurrence of clubfoot was higher than
expected in the investigated region. Hence, it is necessary to establish accurate
diagnostic techniques and clubfoot guidelines to minimize the impact. 相似文献
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Nakanishi Kosuke Usio Nisikawa Yokomizo Hiroyuki Takashima Tadao Hayashi Takehiko I. 《Paddy and Water Environment》2022,20(1):177-183
Paddy and Water Environment - Rice paddy fields are important habitat for many dragonfly species. In Japan, populations of dragonflies inhabiting rice paddies, in particular Sympetrum (Odonata:... 相似文献
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本试验对10头患流行性白血病病牛的不同器官的肿瘤组织,用8种单克隆抗体(McAb),TH14B、BAQ44A、PIg45A、BIg715A、PIg501E、cAct105、MM1A、AHCC125染色进行了观察。结果:病牛经临床病理学和免疫琼扩试验而诊断为EBL,通过免疫组织化学检测,在10个病例中发现有9个病例的肿瘤组织对B细胞属性的McAb有很强的染色反应,证明其来源于B细胞。仅有1个病例对B细胞属性的McAb着色很淡,而对T细胞属性的McAb着色很深,呈强阳性反应,说明其来源可能与T细胞有关。 相似文献
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Purpose To describe a case of superficial keratomycosis caused by Mortierella wolfii (M. wolfii) in a horse. Methods A thoroughbred filly was presented with painful right eye of 2 days’ duration. A superficial corneal ulcer was observed ventrally together with multifocal punctuate opacities axially. Samples were collected by swabbing and scraping the ulcerated lesion and submitted for microbiologic and cytologic examination. Results Microscopic evaluation of debrided corneal tissue revealed the presence of nonseptate fungal hyphae, and culture of a corneal swab yielded fungal growth. Medical treatment with topical antifungal, antibiotic and autogenous serum and systemic anti‐inflammatory resolved the problem within 2 weeks. Conclusions Cytologic evaluation of a corneal scraping was useful to make a clinical diagnosis of keratomycosis. Based on the mycological characteristics, the fungus isolated from the corneal lesion was identified as M. wolfii. To the authors’ knowledge, this is the first case report of equine keratomycosis associated with this fungus, although the organism is known to infect various organs of cattle. 相似文献
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Satake S Nakamura C Minamide Y Kudo S Maeda H Chihaya Y Kamimura Y Miyajima H Sasaki J Goryo M Okada K 《Journal of toxicologic pathology》2010,23(2):75-83
To elucidate the effect of a large dose of di (2-ethylhexyl) phthalate (DEHP), a plasticizer and peroxisome proliferator-activated receptor-α (PPARα) agonist, on hepatic peroxisomes, we orally administered 1,000 mg/kg/day, once daily, to 3 male and 4 female cynomolgus monkeys for 28 days consecutively. Light-microscopic and electron microscopic examinations of the liver were carried out in conjunction with measurement of the hepatic fatty acid β-oxidation system (FAOS), carnitine acetyltransferase (CAT) and carnitine palmitoyltransferase (CPT) activities, which are peroxisomal and/or mitochondrial enzyme activities. Electron microscopically, enlargement of the mitochondria was observed with lamellar orientation of the cristae along the major axis. Although the number of peroxisomes showed a tendency to increase when compared with those in a biopsied specimen before treatment, no abnormality in morphology was observed. A slight increase in CPT activity was noted at termination. No changes were noted in hepatic FAOS or CAT activity. In conclusion, although repeated oral treatment of cynomolgus monkeys with a large dose of DEHP induced a subtle increase in the numbers of peroxisomes with slight enlargements of the mitochondria, this low-sensitivity response to peroxisome proliferators in cynomolgus monkeys was considered to be closer to the response in humans than that in rodents. 相似文献