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Effect of vitamin A deficiency on the activity of macrophages in Newcastle disease virus-infected chickens 总被引:1,自引:0,他引:1
S R Sijtsma J H Rombout M J Dohmen C E West A J van der Zijpp 《Veterinary immunology and immunopathology》1991,28(1):17-27
The effect of vitamin A deficiency on the activity of peritoneal macrophages (PM) was investigated in noninfected and Newcastle disease virus (NDV)-infected chickens. Day-old chickens with limited vitamin A reserves were fed diets containing either marginal (120 retinol equivalents (RE)/kg) or adequate (1200 RE/kg) levels of vitamin A. At 4 weeks of age, half of the chickens in each group were infected with the La Sota strain of NDV and PM were isolated 11 or 12 days later. These were used for counting the uptake of fluorescein isothiocyanate-labeled yeast cells as an indicator of phagocytic activity and for measuring the reduction of nitroblue tetrazolium (NBT), which provides an estimate of oxygen-dependent killing of microorganisms. Vitamin A deficiency impaired NBT reduction and, to a lesser extent, phagocytosis in both infected and noninfected chickens. NDV infection increased phagocytosis and NBT reduction in normal and, to a lesser extent, in vitamin A-deficient chickens. 相似文献
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S R Sijtsma J H Rombout C E West A J van der Zijpp 《Veterinary immunology and immunopathology》1990,26(2):191-201
The effect of vitamin A deficiency on cytotoxic T lymphocyte (CTL) activity was investigated during the acute phase of disease 7 days after primary inoculation and 1 day after secondary inoculation in chickens with or without Newcastle disease virus (NDV, La Sota strain) infection. Day-old chickens with limited vitamin A reserves were fed purified diets containing either marginal (ad libitum) or adequate (pair-fed) levels of vitamin A, and at 3 weeks of age half of the chickens in each group were infected with NDV. Cytotoxic activity was investigated during the acute phase of disease (7 days after primary inoculation) and 1 day after secondary inoculation, in an assay system with either peripheral blood lymphocytes (PBL) or nonadherent splenocytes as effector cells and adherent splenocytes from the same animal as target cells. After primary inoculation, cytotoxic activity could only be demonstrated in nonadherent splenocytes. Vitamin A deficiency resulted in significantly reduced CTL activity at all effector/target cell ratios tested. After reinfection CTL activity could also be demonstrated in PBL, but only from chickens fed the control diet, suggesting a diminished pool of CTL in vitamin A deficiency. The results of this study indicate that vitamin A deficiency impairs CTL activity - a part of the cell-mediated defense system - and this may have important implications for recovery from viral infection. 相似文献
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Sijtsma Frans J. van der Veen Eelke van Hinsberg Arjen Pouwels Rogier Bekker Renée van Dijk René E. Grutters Mark Klaassen Raymond Krijn Margriet Mouissie Maarten Wymenga Eddy 《Landscape Ecology》2020,35(7):1701-1720
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Angelstam Per Manton Michael Elbakidze Marine Sijtsma Frans Adamescu Mihai Cristian Avni Noa Beja Pedro Bezak Peter Zyablikova Iryna Cruz Fatima Bretagnolle Vincent Díaz-Delgado Ricardo Ens Bruno Fedoriak Mariia Flaim Giovanna Gingrich Simone Lavi-Neeman Miri Medinets Sergey Melecis Viesturs Muñoz-Rojas Jose Schäckermann Jessica Stocker-Kiss Andrea Setälä Heikki Stryamets Natalie Taka Maija Tallec Gaelle Tappeiner Ulrike Törnblom Johan Yamelynets Taras 《Landscape Ecology》2019,34(7):1461-1484
Landscape Ecology - Place-based transdisciplinary research involves multiple academic disciplines and non-academic actors. Long-Term Socio-Ecological Research (LTSER) platform is one concept with ~... 相似文献
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Landscape Ecology - The governance of international natural World Heritage sites is extremely challenging. In the search for effective multilevel governance there is a need to identify the... 相似文献
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