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M. Ryan Smith DVM DACVECC Virginie A. Wurlod MS Dr vet med DACVECC DECVECC Chin-Chi Liu MS MApStat PhD 《Journal of Veterinary Emergency and Critical Care》2023,33(6):648-655
Objective
To describe hemostatic derangements associated with canine anaphylaxis and to assess for association with syndrome severity.Design
Prospective observational study.Setting
University teaching hospital.Animals
Twenty-seven client-owned dogs, recruited from November 2018 to January 2022, diagnosed with anaphylaxis of varying severity were included. Study inclusion required presentation <6 hours after initiation of clinical signs, no medications or history of illness within the prior 2 weeks, lack of comorbidities expected to affect hemostasis, and lack of a disease state that could alternatively explain the clinical presentation.Interventions
Blood samples were collected within the first hour of presentation for CBC, serum biochemistry, prothrombin time (PT), activated partial thromboplastin time (aPTT), and viscoelastic coagulation testing for use with a cartridge-based point-of-care device.Measurements and main results
Clotting time and clot formation time were prolonged, alpha angle and maximum clot firmness were decreased, PT and aPTT were prolonged, and platelet counts were lower in severe cases compared to mild and moderate cases. There were no differences for any parameter between mild and moderate cases. The presence or absence of abdominal effusion was not associated with hemostatic status.Conclusions
Global hemostatic derangements consistent with hypocoagulability are a prominent feature of severe anaphylaxis in dogs and should be considered for routine evaluation. 相似文献2.
Karanvir S. Aulakh BVSc & AH MS MS CCRP DACVS-SA Kaustubh R. Dongaonkar BVSc & AH MVSc Katherine Barnes DVM MS CCRP DACVS-SA Alberto J. Gines DVM DECVS Jude T. Bordelon DVM MS MBA DACVS-SA Don Hulse DVM DACVS DECVS Harmeet K. Aulakh BVSc & AH MVSc DACVIM Chin-Chi Liu MS MApStat PhD 《Veterinary surgery : VS》2020,49(3):455-462
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Triglyceride, Insulin, and Cortisol Responses of Ponies to Fasting and Dexamethasone Administration 总被引:1,自引:0,他引:1
J. F. Freestone BVSc K. J. Wolfsheimer DVM PhD R. B. Ford DVM MS G. Church MApStat R. Bessin MApStat PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1991,5(1):15-22
Ponies were evaluated for their response to feed withholding and exogenous administration of corticosteroids (dexamethasone 0.04 mg/kg intramuscular [IM]) in an attempt to reproduce the hyperlipemia syndrome. Because insulin resistance has been associated with hyperlipemia, all ponies were initially evaluated for insulin response to an oral glucose load and normal dexamethasone suppression of serum cortisol. Four ponies were identified as hyperinsulinemic reflecting insulin resistance. All ponies had suppressed cortisol concentrations following dexamethasone administration. Feed withdrawal resulted in hypertriglyceridemia by 48 hours in all ponies. Very low density lipoprotein-triglyceride (VLDL) fraction was primarily elevated. The administration of dexamethasone failed to increase the degree of triglyceridemia. Although insulin resistance has been proposed as the likely cause of the hypertriglyceridemia in ponies, in this study four of eight ponies were considered to have normal insulin responses and yet still developed hypertriglyceridemia. 相似文献
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