Computing inbreeding coefficients and the inverse numerator relationship matrix in large populations of honey bees

The inbreeding coefficients are considered in breeding decisions, and the inverse numerator relationship matrix A ^?1 is a prerequisite for breeding value estimation. Polyandry and haploid males are among the specifics of relationships between honey bees. Brascamp and Bijma (2014) averaged out the manifold possible relationships among honey bees that appear to have the same parents in a pedigree and assigned a single entry in A to animals that behave as a unit, for example, the workers of a hive. Their methods of calculation connected full‐sibs in the variance matrix of the Mendelian sampling terms D , via nonzero off‐diagonal elements. This impedes the inversion of A and the closely connected calculation of inbreeding coefficients, because efficient algorithms for this task take D to be a diagonal matrix. Memory limitations necessitate their use for large data sets. We adapted the quickest of them to the block diagonal matrix D , that is postulated for the honey bee. To our knowledge, the presented algorithm is the first one that facilitates the method of Brascamp and Bijma (2014) on large data sets.     

Cystinuria in the dog: clinical studies during 14 years of medical treatment

The purpose of this study was to summarize 14 years of clinical experience with medical treatment of 88 cystinuric dogs. Of special interest was evaluation of recurrence rate of cystine uroliths and adverse effects during long-term tiopronin treatment. Twenty-six different breeds were recognized, and the most common breeds were Dachshunds, Tibetan Spaniels, and Basset Hounds. In 76 of 88 treated dogs (86%), re-formation of cystine uroliths was prevented. Recurrence rate of cystine uroliths changed from 7 months before to 18 months during tiopronin treatment. On 28 occasions, bladder stones were found, and in about 60% of the dogs, the uroliths dissolved. Quantitative measurement of the urinary excretion of cystine showed a significantly (P < .03) higher excretion of cystine in dogs with recurrent urolith formation than in dogs with only 1 urolith episode. Another finding was a significant (P = .02) decrease in urinary cystine excretion in older (>5 years) than in younger (<5 years) dogs. Adverse effects were found in 11 dogs, and the most severe signs were aggressiveness and myopathy. All signs disappeared when tiopronin treatment was stopped. In conclusion, this study emphasizes the importance of an individual strategy for lifelong treatment of cystinuria. In addition to increasing water intake, chemical modification of the cysteine molecule into a more soluble form by means of tiopronin is useful. In dogs with re-formed cystine uroliths, dissolution may be induced by increasing the tiopronin dosage to 40 mg/kg body weight per day. In dogs with a low urolith recurrence rate and low urinary cystine excretion, the tiopronin dosage may be decreased or treatment discontinued.     

A COMPUTED TOMOGRAPHIC STUDY OF VOLUME AND X-RAY ATTENUATION OF THE LUNGS OF BEAGLES IN VARIOUS BODY POSITIONS

The influence of body position on volume and x-ray attenuation of the lungs of three Beagles was investigated with computed tomography. In left and right lateral recumbency, the dependent lung had decreased volume and increased x-ray attenuation compared with ventral recumbency. Volume and x-ray attenuation of the nondependent lung, however, were unchanged. In dorsal recumbency, there was a vertical gradient of x-ray attenuation being increased dorsally and decreased ventrally compared with ventral recumbency where regional differences in x-ray attenuation were not found. Results indicate a risk of overlooking a mass in the dependent pulmonary parenchyma of dogs in lateral and dorsal recumbency. Regional differences in x-ray attenuation of the lungs of dogs can be avoided if the radiographs are obtained with the dog in ventral recumbency.     

Impact features on Stardust: implications for comet 81P/Wild 2 dust

Particles emanating from comet 81P/Wild 2 collided with the Stardust spacecraft at 6.1 kilometers per second, producing hypervelocity impact features on the collector surfaces that were returned to Earth. The morphologies of these surprisingly diverse features were created by particles varying from dense mineral grains to loosely bound, polymineralic aggregates ranging from tens of nanometers to hundreds of micrometers in size. The cumulative size distribution of Wild 2 dust is shallower than that of comet Halley, yet steeper than that of comet Grigg-Skjellerup.     

Fast variability of tera-electron volt gamma rays from the radio galaxy M87

The detection of fast variations of the tera-electron volt (TeV) (10(12) eV) gamma-ray flux, on time scales of days, from the nearby radio galaxy M87 is reported. These variations are about 10 times as fast as those observed in any other wave band and imply a very compact emission region with a dimension similar to the Schwarzschild radius of the central black hole. We thus can exclude several other sites and processes of the gamma-ray production. The observations confirm that TeV gamma rays are emitted by extragalactic sources other than blazars, where jets are not relativistically beamed toward the observer.     

Auslösung der Phytoalexinanreicherung durch Infektionen oder Elicitoren

Phytoalexins are antimicrobial compounds accumulating in infected plants. Accumulation of phytoalexins has been observed after infections by fungi, bacteria, viruses, and nematodes. Their formation is often associated with cellular necrosis. Evidence exists that the accumulation is based on enhanced de novo synthesis of phytoalexins in living cells adjacent to the necrotic tissue. Antifungal activity of phytoalexins is directed against different pathogenic and nonpathogenic fungi. In some instances, they may contribute to nonhost resistance; in other cases, they might be involved in plant resistance against pathogens. Numerous abiotic inducers of phytoalexin formation are known and highly potent elicitors of phytoalexins have been isolated from fungal cell walls and culture fluids. Keen and associates reported that races ofPhytophthora megasperma produce specific elicitors of phytoalexin formation which are active only in resistant interactions. Albersheim and associates purified and characterized phytoalexin-eliciting -glucans from the same fungus which unspecifically induce phytoalexin accumulation in resistant, susceptible, and also in nonhost plants. Research on elicitors should provide powerful tools for the elucidation of phytoalexin biosynthesis and the role of phytoalexins in plant resistance.

---

---

Vortrag, gehalten auf der XVI. Vortrags-Tagung der Deutschen Gesellschaft für Qualitätsforschung (Pflanzliche Nahrungsmittel) (DGQ), am 20.3.1980 in Hamburg.     

Light modification in a developing silvopastoral system in the UK: a quantitative analysis

Transmitted photosynthetically active radiation (PAR) was measured in eight-year-old silvopastoral stands at three different locations in the UK by using PAR sensors randomly distributed between four adjacent trees planted in a square pattern. Two densities (100 stems.ha^-1 and 400 stems.ha^-1 were compared. The annual carrying capacity (live weight of the animals that a plot supports) was also recorded as an indirect figure of the overall agricultural production of the system. The silvopastoral plots received less radiation than the agricultural plot without trees, the 400 stems.ha^-1 treatment being more shaded than the 100 stems.ha^-1. Over the measurement period, on some special days, a maximum of 30% of the incoming radiation was intercepted on the 400 stem.ha^-1 treatment with the largest trees. The amount of light intercepted was highly correlated with the type of weather and the leaf area development of the trees: the brighter the day and more expanded the leaf area, the higher was the proportion of radiation intercepted by the tree. However, over the measuring period, a small amount of radiation was intercepted by the tree canopies. As a consequence, no differences were observed in the annual carrying capacity. This revised version was published online in June 2006 with corrections to the Cover Date.     

On the mode of action of 3-phenylindole towards Aspergillus niger

3-Phenylindole is an antimicrobial compound active towards many fungi and gram-positive bacteria. At 5 μg/ml it inhibits growth of Aspergillus niger. Higher concentrations (50 μg/ml) also suppress spore germination; they do not kill the fungus. Dry weight of the fungus still increases for 1 or 2 days after fungicide treatment. The toxicant has no effect on O₂ uptake even at higher concentrations (100 μg/ml). The compound markedly affects composition of the lipid fraction of A. niger inducing a decrease in phospholipid concentration with a coincident increase in free fatty acids. Sterol pattern and sterol concentration were not affected. Antifungal activity was reversed by phospholipids added to the medium. 3-Phenylindole induced a slight leakage of ³²P-labeled compounds from the treated cells under growth conditions but not under nongrowth conditions. A strain of A. niger resistant to 3-phenylindole had the same phospholipid and sterol pattern as the wild type, but the level of both components was higher (40–60%). The 3-phenylindole-resistant strain showed resistance to triarimol and pimaricin. The wild type and the resistant strain both took up 3-phenylindole quite rapidly and accumulated it in the mycelium. 3-Phenylindole possibly interferes with phospholipid function in cell membranes, although the specific site of action has not yet been elucidated.