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NISHIMURA ET HAMILTON HB KOBARA TY TAKAHARA S OGURA Y DOI K 《Science (New York, N.Y.)》1959,130(3371):333-334
The heterozygous carrier state of a rare hereditary disease, acatalasemia, has been defined biochemically. Affected homozygotes have no blood catalase activity, whereas heterozygotes show activities intermediate between this inactivity and the activity of normal controls, without overlap. Pedigrees show a high frequency of consanguineous marriages. 相似文献
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Ei-ichirou TAKAHARA Hideto YUASA Miho NISHIDA Youhei MANTANI Kankanam Gamage Sanath UDAYANGA Wang-Mei QI Takashi TAKEUCHI Toshifumi YOKOYAMA Nobuhiko HOSHI Hiroshi KITAGAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(4):387-393
A portion of the minute chylomicrons less than 75 nm in diameter are transcytosed from
the extravascular tissue into the subepithelial blood capillaries (sBC) in the villous
apices of the rat jejunum. However, the details of the transportation mechanism have not
been clarified. In this study, the endothelial receptor involved in the transportation of
minute chylomicrons into the sBC’s lumina was immunohistochemically and
histoplanimetrically examined in intestinal villi of the rat jejunum. Immunopositivity for
very low density lipoprotein (VLDL) receptor was detected on the luminal and basal
surfaces of the endothelial cells of sBC in approximately 68% of those apices of jejunal
villi that possessed numerous chylomicrons in the lamina propria, while VLDL receptor was
detected on the endothelial cells of sBC in only approximately 8% of intestinal villi that
possessed few or no chylomicrons in the lamina propria. No immunopositivity for LDL
receptor was detected in the sBC of all intestinal villi. These findings suggest that VLDL
receptor is expressed by the endothelial cells of the sBC in conjunction with the filling
of the lamina propria of jejunal villi with many chylomicrons produced by the villous
columnar epithelial cells and that the VLDL receptor mediates the transportation of minute
chylomicrons, maybe VLDL, into the subepithelial portal blood from the extravascular
tissue of the rat jejunal villi. 相似文献
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Ampaabeng Gyedu KYEREMEH Toshio KIKUMOTO Duen-yau CHUANG Yuichi GUNJI Yoshiyuki TAKAHARA Yoshio EHARA 《Journal of General Plant Pathology》2000,66(3):264-268
Two pathogenic strains of E. carotovora subsp. carotovora 2T-2 and TT-4 with high bacteriocin activity but low sensitivity to the bacteriocins of other strains were treated with ethyl
methane sulphonate (EMS). Two avirulent mutants A-f-39 and B-e-19 developed from 2T-2 and TT-4, respectively, by this treatment
had the same bacteriocin activity as their respective parents and inhibited the in vitro growth of pathogenic strains of this species. The disease control of these two mutant strains were compared in the field in
1995 and 1997 to the control by CGE234M403 (M403) (a commercialized biocontrol agent), a mixture of A-f-39 and M403, and an
agrochemical (basic dithianon-copper chloride). The protection obtained with A-f-39 was comparable to M403 and was better
than that with the chemical. The mixture of A-f-39 and M403 consistently gave the best results in all the field trials.
Received 17 September 1999/ Accepted in revised form 22 February 2000 相似文献
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Yokoo Y Miyata H Udayanga KG Qi WM Takahara E Yokoyama T Kawano J Hoshi N Kitagawa H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(2):217-225
To clarify the fundamental regulation mechanism against indigenous bacterial proliferation in the alimentary tract, we immunohistochemically examined the localization of 4 bactericidal peptides (BP) in the rat digestive exocrine glands. In the upper alimentary tract, lysozyme was detected in the gustatory, extraorbital lacrimal and parotid glands. Secretory phospholipase A2 (sPLA2) was detected in the extraorbital lacrimal glands. β-defensin1 was detected in the gustatory and extraorbital lacrimal glands. β-defensin2 was detected in the Harderian glands. In the stomach, β-defensins were detected in the gastric superficial epithelial cells. In the small and large intestines, only lysozyme and sPLA2 were detected in the Paneth cells. In the cecum, all 4 BP were detected in the middle to apical portions of the crypts, and only sPLA2 was detected in the basal portion. No BP were localized in other exocrine glands associated with the alimentary tract. In addition, all 4 BP were also detected in the columnar epithelial cells of the apical portions of intestinal villi. In the intestinal superficial epithelial cells, lysozyme and β-defensins were detected in the ascending colon, whereas only β-defensin1 was detected in the descending colon and rectum. These results suggest that BP are mainly secreted from exocrine tissues in the initial portion of the digestive tract and play a role in host defense against indigenous bacteria throughout the digestive tract. Part of the BP in the chyme might be absorbed by the epithelium at the most inner sites of mucosae in the small and large intestines. 相似文献
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