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排序方式: 共有176条查询结果,搜索用时 31 毫秒
1.
Y Nagashima H Hirao S Furukawa K Hoshi M Akahane R Tanaka Y Yamane 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(11):1199-1202
Fifteen and eight mature beagles, without (normal group) and with experimental mitral regurgitation (MR group), respectively, were given 0.02 mg/kg/day digoxin powder for 10 days orally. The optimum time for sample collection after administration of digoxin was observed to be 8-18 hr and 10-22 hr in the normal and MR groups, respectively. In both groups, a stable concentration was reached after 3-5 days of treatment. No differences in plasma level were observed between sexes. The optimum concentration of digoxin was attained at an earlier stage than has been previously reported for both dogs and humans. 相似文献
2.
Cellular injury and lipid peroxidation induced by hexavalent chromium in isolated rat hepatocytes 总被引:1,自引:0,他引:1
S Ueno N Susa Y Furukawa K Aikawa I Itagaki 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1989,51(1):137-145
In order to elucidate the relationship between cellular injury and lipid peroxidation induced by hexavalent chromium (CrVI), isolated rat hepatocytes treated with any one of scavengers of active oxygen species, antioxidants or antichromium agent were incubated with K2Cr2O7 as CrVI (1 mM Cr). After the incubation, the development of lipid peroxidation was determined as thiobarbituric acid (TBA)-reacting materials in total lipid extracts from the incubated hepatocytes. Cellular injury was observed as a leakage of lactate dehydrogenase (LDH) from hepatocytes into incubation medium. The contents of reduced glutathione (GSH) in hepatocytes were also assessed. Results obtained were as follows: (1) CrVI facilitated lipid peroxidation in isolated hepatocytes after 20 min of incubation. On the other hand, the cellular injury induced by CrVI was barely observed even after 60 min of incubation. (2) The CrVI-induced lipid peroxidation was inhibited by catalase and mannitol as scavengers of active oxygen species, or N,N'-diphenyl-p-phenylenediamine and alpha-tocopherol as antioxidants. However the cytotoxicity of CrVI could not be prevented by these chemicals. (3) CrVI depleted the contents of intracellular GSH and diminished the activities of glutathione reductase (GR) and glutathione-S-transferase (GST) except glutathione peroxidase. (4) The scavengers of active oxygen species and the antioxidants could not prevent the depletion of intracellular GSH induced by CrVI. (6) Ascorbic acid, antichromium agent, prevented all of the lipid peroxidation, the cellular injury and intracellular GSH depletion induced by CrVI.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
3.
Furukawa S Kobayashi K Usuda K Tamura T Miyamoto Y Hayashi K Ikeyama S Goryo M Okada K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》1999,61(1):41-44
A pinealoma (benign) was found in a 61-week-old male Crj:CD (SD) IGS rat. The neoplasm was located between the cerebral hemispheres and the cerebellum. Histologically, the tumor cells consisted of two cell types: large, pale-staining cells and small dark-staining cells. A fibrovascular stroma divided the tumor cells into incomplete lobules or nest structures. Relatively numerous mitoses were noted in the tumor cells. Ultrastructurally, the tumor cells contained dense-cored vesicles, approximately 120 nm in diameter. 相似文献
4.
Furukawa M Wada N Tokuriki M Miyata H 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2000,62(9):1005-1007
The spinal projections of afferent fibers innervating the facet joints between caudal vertebrae were examined by the use of anterograde transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP). Experiments were performed on 5 adult cats in which spinal dorsal roots below the 2nd sacral segment (S2) on the right side were cut. Injections of WGA-HRP into the caudal facet joints gave rise to extensive cranio-caudal distribution of WGA-HRP positive products along the spinal cord, indicating that many afferent fibers innervating unilateral facet joints terminate bilaterally in laminae I-II, V-VI and X of the thoracic, lumbar, sacral and caudal spinal cord. These afferent fibers may convey a series of sensory information from the caudal facet joints to the spinal cord. 相似文献
5.
Anatomical variations in wood among four native species of Leguminosae grown in arid areas of China 总被引:1,自引:0,他引:1
Yang Shu-min Jiang Ze-hui Ren Hai-qing Ikuo Furukawa 《中国林学(英文版)》2007,9(1):39-44
Morphological features and anatomical variations are described and illustrated in detail for four native species of Legumi-nosae grown in arid sandy regions in China, which are Hedysarum scoparium Fisch.et Mey., Caragana korshiskii Kom., Lespedeza bicolor Turcz. and Ammopiptanthus mongolicus (Maxim. ex Kom.) Cheng f. All species showed similar morphological features: distinct growth ring boundaries, ring to semi-ring-porosity, simple perforation plates, alternate intervessel pitting, nonseptate fibers, para... 相似文献
6.
Masaki Jinkawa Hirokazu Yamaguchi Kuniaki Furukawa Toshiaki Satake Hiroshi Kobayashi 《Journal of Forest Research》2006,11(2):77-88
For monorail systems, it is very important to ensure the safety of the ground structure. We developed a tram car for slopes
that utilizes the mechanism of the monorail and analyzed the stress of the ground structure that had double rails. First,
we divided the ground structure into seven components, and formulated a procedure for calculating the stress of the ground
structure. As a result, the stress that acts upon the main rail and the main rail connecting part was near the allowable stress,
and each calculated value was within the allowable stress. We measured the stress by running the vehicle, and compared the
measured values with the calculated values. As a result, some measured values were larger than the calculated values. However,
the ratio of measured value to allowable stress was 90% or less. Finally, we calculated the static loading coefficient for
each part, results of which were as follows: main and subrail: 1.1; rail connection part and prop foundation part: 1.0; rail
installation part: 1.3. In the recalculations, it became clear that the recalculated values exceeded the allowable stresses.
These results suggest that we need to review the ground structure materials. 相似文献
7.
Characterization of the products resulting from ethylene glycol liquefaction of cellulose 总被引:9,自引:0,他引:9
The composition of liquefied cellulose in the presence of ethylene glycol (EG) was studied. The liquefied products were fractionated and analyzed with highperformance liquid chromatography and nuclear magnetic resonance. EG-glucosides were detected as the only saccharides and 2-hydroxyethyl levulinate as the highly decomposed compound derived from cellulose. Quantitative analysis of the EG-glucosides and levulinic acid that comes from the levulinate shows the presence of the following mechanism in the EG-liquefaction of cellulose. First, cellulose is degraded and produces considerable amounts of EG-glucosides during the early stage of liquefaction. Then, when liquefaction is prolonged, the glucosides are decomposed, leading to a large quantity of levulinates. 相似文献
8.
Tatsuhiko Yamada Masako Aratani Satoshi Kubo Hirokuni Ono 《Journal of Wood Science》2007,53(6):487-493
Degradation and decomposition of cellulose were studied in an acid-catalyzed solvolysis treatment of biomass using polyethylene
glycol (PEG) and ethylene carbonate (EC). The solvolysis reaction was followed by a typical reaction system of wood liquefaction
that uses sulfuric acid catalyst at 140° or 150°C at atmospheric pressure. The methods of fractionation and chemical analysis
of the degraded cellulose in the solvolyzed product are discussed. The solvolyzed product was separated into several fractions,
and they were hydrolyzed to release glucose and levulinic acid to determine the quantity of glucosides and levulinates in
the solvolysis product. The data clearly showed that the solvolysis reaction had the same mechanism when using PEG or EC.
Degradation of cellulose leads to the formation of glucosides, which then decompose, resulting in a levulinic acid structure,
and producing a water-insoluble fraction. The conversion rates of both glucosides and levulinates strongly depend on the reaction
conditions of the solvolysis. In particular, EC promotes faster conversion of the reactions. The method discussed here is
a chemical analytical technique for characterization of the products of wood liquefaction. 相似文献
9.
Takaya Y Furukawa T Miura S Akutagawa T Hotta Y Ishikawa N Niwa M 《Journal of agricultural and food chemistry》2007,55(1):75-79
Constituents in a distillation residue of Awamori (millet spirits) and their antioxidant activity are investigated in this study. The supernatant of the distillation residue obtained by centrifugation was partitioned with n-hexane, chloroform, ethyl acetate, and n-butanol against water to afford the corresponding solubles. Among them, n-hexane and chloroform solubles showed higher antioxidant potency than l-ascorbic acid by the bleomycin-Fe method. In chloroform solubles, seven cyclic dipeptides were identified along with ethyl 2-pyrrolidione-5-carboxylate, tyrosol, and ethyl p-hydoroxyphenyllactate. Antioxidant activity of ethyl p-hydoroxyphenyllactate was 4.2 times that of l-ascorbic acid, whereas cyclic dipeptides showed activity 0.89-1.29 times as strong as that of l-ascorbic acid. On the other hand, scavenging effect of cyclic dipeptides against O(2)(-.) and OH(.) by using electron spin resonance was also investigated. In the results, cyclo(l-Ile-l-Pro) showed significantly strong inhibitory effect against OH(.) (95.4% at 2.5 x 10-3 M) and cyclo(l-Phe-l-Pro), cyclo(l-Pro-l-Val), and cyclo(l-Leu-l-Pro) inhibited OH(.) 64.9, 54.1, and 51.0%, respectively, whereas alpha-tocopherol showed 37.7% inhibition, though only a few cyclic dipeptides weakly inhibited O(2)(-.). 相似文献
10.
The primary function of the placenta is to act as an interface between the dam and fetus. The anatomic structure of the chorioallantoic placenta in eutherian mammals varies between different animal species. The placental types in eutherian mammals are classified from various standpoints based on the gross shape, the histological structure of the materno-fetal interface, the type of materno-fetal interdigitation, etc. Particularly, the histological structure is generally considered one of the most useful and instructive classifications for functionally describing placental type. In this system, three main types are recognized according to the cell layers comprising the interhemal area: (1) epitheliochorial type (horses, pigs and ruminants), (2) endotheliochorial type (carnivores) and (3) hemochorial type (primates, rodents and rabbits). The number of cell layers in the interhemal area is considered to modify the transfer of nutrients between maternal and fetal blood and is one of the important factors with respect to the difference in placental permeability between animal species. Therefore, in reproductive and developmental toxicity studies, careful attention should be paid to the histological structure of the interhemal area when extrapolating information concerning placental transfer characteristics to different animal species. 相似文献