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Jun TAMURA Tomohito ISHIZUKA Sho FUKUI Norihiko OYAMA Kodai KAWASE Kenjiro MIYOSHI Tadashi SANO Kirby PASLOSKE Kazuto YAMASHITA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(3):289-296
The pharmacological effects of the anesthetic alfaxalone were evaluated after
intramuscular (IM) administration to 6 healthy beagle dogs. The dogs received three IM
doses each of alfaxalone at increasing dose rates of 5 mg/kg (IM5), 7.5 mg/kg (IM7.5) and
10 mg/kg (IM10) every other day. Anesthetic effect was subjectively
evaluated by using an ordinal scoring system to determine the degree of neuro-depression
and the quality of anesthetic induction and recovery from anesthesia. Cardiorespiratory
variables were measured using noninvasive methods. Alfaxalone administered IM produced
dose-dependent neuro-depression and lateral recumbency (i.e., 36 ± 28 min, 87 ± 26 min and
115 ± 29 min after the IM5, IM7.5 and IM10 treatments, respectively). The endotracheal
tube was tolerated in all dogs for 46 ± 20 and 58 ± 21 min after the IM7.5 and IM10
treatments, respectively. It was not possible to place endotracheal tubes in 5 of the
6 dogs after the IM5 treatment. Most cardiorespiratory variables remained
within clinically acceptable ranges, but hypoxemia was observed by pulse oximetry for 5 to
10 min in 2 dogs receiving the IM10 treatment. Dose-dependent decreases in rectal
temperature, respiratory rate and arterial blood pressure also occurred. The quality of
recovery was considered satisfactory in all dogs receiving each treatment; all the dog
exhibited transient muscular tremors and staggering gait. In conclusion, IM alfaxalone
produced a dose-dependent anesthetic effect with relatively mild cardiorespiratory
depression in dogs. However, hypoxemia may occur at higher IM doses of alfaxalone. 相似文献
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Keisuke KAWASE Jumpei TOMIYASU Kazuyuki BAN Ryosuke ONO Satoshi ANDO Aya ONO Ran KIMURA Kanako TOMISAWA Motozumi MATSUI Shun-ichi SHIIHARA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(9):1454
Lions (Panthera leo) breed well under captivity, so contraception has been commonly conducted for population management, leading to a demand for a less invasive and reversible contraceptive approach in lions. In this study, we examined the efficacy of a commercial gonadotropin-releasing hormone vaccine as a method of suppressing reproductive activity in a sexually matured female lion. Under behavioral restraint, the vaccine was injected twice (days 0 and 109). After the initial vaccination, ovarian activity is still observed. After the second vaccination, contraceptive effect was confirmed for 246 days until restart of estrous cycles. We confirmed only a slight swelling around the injection site after the second vaccination. This study may suggest an alternative option for a contraceptive method in lions. 相似文献
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Mohammed Ahmed UMAR Sho FUKUI Kodai KAWASE Takaharu ITAMI Kazuto YAMASHITA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(3):281-288
Cardiovascular effects of total intravenous anesthesia using
ketamine-medetomidine-propofol drug combination (KMP-TIVA) were determined in 5
Thoroughbred horses undergoing surgery. The horses were anesthetized with intravenous
administration (IV) of ketamine (2.5 mg/kg) and midazolam (0.04 mg/kg) following
premedication with medetomidne (5 µg/kg, IV) and artificially ventilated.
Surgical anesthesia was maintained by controlling propofol infusion rate (initially 0.20
mg/kg/min following an IV loading dose of 0.5
mg/kg) and constant rate infusions of ketamine (1 mg/kg/hr) and medetomidine
(1.25 µg/kg/hr). The horses were anesthetized for 175 ± 14 min (range
from 160 to 197 min). Propofol infusion rates ranged from 0.13 to 0.17 mg/kg/min, and
plasma concentration (Cpl) of propofol ranged from 11.4 to 13.3
µg/ml during surgery. Cardiovascular measurements
during surgery remained within clinically acceptable ranges in the horses (heart rate: 33
to 37 beats/min, mean arterial blood pressure: 111 to 119 mmHg, cardiac index: 48 to 53
ml/kg/min, stroke volume: 650 to 800 ml/beat and
systemic vascular resistance: 311 to 398 dynes/sec/cm5). The propofol Cpl
declined rapidly after the cessation of propofol infusion and was significantly lower at
10 min (4.5 ± 1.5 µg/ml), extubation (4.0 ± 1.2
µg/ml) and standing (2.4 ± 0.9
µg/ml) compared with the Cpl
at the end of propofol administration (11.4 ± 2.7
µg/ml). All the horses recovered uneventfully and stood
at 74 ± 28 min after the cessation of anesthesia. KMP-TIVA provided satisfactory quality
and control of anesthesia with minimum cardiovascular depression in horses undergoing
surgery. 相似文献
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