排序方式: 共有3条查询结果,搜索用时 0 毫秒
1
1.
Tsiailanis Antonios D. Chatzigiannis Christos M. Papaemmanouil Christina D. Chatziathanasiadou Maria V. Chaloulos Panagiotis Riba Isabel Mullard Graham Wiczkowski Wiesław Koutinas Apostolos Mandala Ioanna Tzakos Andreas G. 《Plant foods for human nutrition (Dordrecht, Netherlands)》2022,77(2):198-205
Plant Foods for Human Nutrition - Replacing synthetic dyes with natural pigments has gained great attention over the past years in the food industry, due to the increased alertness of consumers for... 相似文献
2.
Charisiadis P Tsiafoulis CG Exarchou V Tzakos AG Gerothanassis IP 《Journal of agricultural and food chemistry》2012,60(18):4508-4513
A rapid and direct low micromolar 1H NMR method for the simultaneous identification and quantification of hydrogen peroxide and phenolic compounds in plant extracts was developed. The method is based on the highly deshielded 1H NMR signal of H?O? at ~10.30 ppm in DMSO-d? and the combined use of picric acid and low temperature, near the freezing point of the solution, in order to achieve the minimum proton exchange rate. Line widths of H?O? below 3.8 Hz were obtained for several Greek oregano extracts which resulted in a detection limit of 0.7 μmol L?1. Application of an array of NMR experiments, including 2D 1H-13C HMBC, spiking of the samples with H?O?, and variable temperature experiments, resulted in the unequivocal assignment of H?O? precluding any confusion with interferences from intrinsic phenolics in the extract. 相似文献
3.
Tzakos AG Kontogianni VG Tsoumani M Kyriakou E Hwa J Rodrigues FA Tselepis AD 《Journal of agricultural and food chemistry》2012,60(28):6977-6983
Betulinic acid, a natural pentacyclic triterpene acid, presents a diverse mode of biological actions including antiretroviral, antibacterial, antimalarial, and anti-inflammatory activities. The potency of betulinic acid as an inhibitor of human platelet activation was evaluated, and its antiplatelet profile against in vitro platelet aggregation, induced by several platelet agonists (adenosine diphosphate, thrombin receptor activator peptide-14, and arachidonic acid), was explored. Flow cytometric analysis was performed to examine the effect of betulinic acid on P-selectin membrane expression and PAC-1 binding to activated platelets. Betulinic acid potently inhibits platelet aggregation and also reduced PAC-1 binding and the membrane expression of P-selectin. Principal component analysis was used to screen, on the chemical property space, for potential common pharmacophores of betulinic acid with approved antithrombotic drugs. A common pharmacophore was defined between the NMR-derived structure of betulinic acid and prostacyclin agonists (PGI2), and the importance of its carboxylate group in its antiplatelet activity was determined. The present results indicate that betulinic acid has potential use as an antithrombotic compound and suggest that the mechanism underlying the antiplatelet effects of betulinic acid is similar to that of the PGI2 receptor agonists, a hypothesis that deserves further investigation. 相似文献
1