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1.
Takumi KOMIYA Akihiro MORI Naohito NISHII Hitomi ODA Eri ONOZAWA Seri SEKI Toshinori SAKO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):661
A 5-year-old castrated male domestic shorthair cat was diagnosed with diabetic ketoacidosis and severe insulin resistance. Although the conventional treatment for diabetic ketoacidosis was provided, the cat required frequent hospitalization because of severe dehydration and repeated diabetic ketoacidosis. We detected anti-insulin antibodies for human in this cat. Serum insulin-binding IgG levels were markedly elevated compared with those in healthy cats and other diabetic cats. We initiated prednisolone to suppress the effects of anti-insulin antibodies. After initiation of prednisolone, the cat was gradually recovered with increasing activity and appetite. Furthermore, satisfactory glycemic control was achieved with combined subcutaneous injection of insulin detemir and insulin degludec. 相似文献
2.
Jaroenporn S Nagaoka K Ohta R Watanabe G Taya K 《The Journal of reproduction and development》2007,53(4):887-893
Prolactin (PRL) has been proposed to directly stimulate corticosterone release. However, the role of PRL on adrenocortical function in male HAA rats has not been fully clarified. The aim of this study was to investigate the effect of PRL on the secretion of corticosterone and progesterone using an in vitro cell culture system in male rats. Administration of PRL (10(-7) and 10(-6) M) resulted in dose-dependent increases in corticosterone and progesterone release. Cotreatment with PRL produced an increase in the stimulatory effects of ACTH-induced corticosterone and progesterone secretion. However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor. In addition, administration of AG490 blunted the significant inhibition of ACTH-induced corticosterone and progesterone secretion by PRL. These results demonstrated that PRL could act directly on the adrenal gland to drive corticosterone and progesterone secretion in male rats. Additionally, the results emphasize that PRL stimulation of adrenal steroid release may be mediated through Jak2 activity. 相似文献
3.
Masahiro MIYABE Azusa GIN Eri ONOZAWA Mana DAIMON Hana YAMADA Hitomi ODA Akihiro MORI Yutaka MOMOTA Daigo AZAKAMI Ichiro YAMAMOTO Mariko MOCHIZUKI Toshinori SAKO Katsutoshi TAMURA Katsumi ISHIOKA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1201-1206
G protein-coupled receptor (GPR) 120 is an unsaturated fatty acid receptor, which is
associated with various physiological functions. It is reported that the genetic variant
of GPR120, p.Arg270His, is detected more in obese people, and this genetic variation
functionally relates to obesity in humans. Obesity is a common nutritional disorder also
in dogs, but the genetic factors have not ever been identified in dogs. In this study, we
investigated the molecular structure of canine GPR120 and searched for candidate genetic
variants which may relate to obesity in dogs. Canine GPR120 was highly homologous to those
of other species, and seven transmembrane domains and two N-glycosylation sites were
conserved. GPR120 mRNA was expressed in lung, jejunum, ileum, colon, hypothalamus,
hippocampus, spinal cord, bone marrow, dermis and white adipose tissues in dogs, as those
in mice and humans. Genetic variants of GPR120 were explored in client-owned 141 dogs,
resulting in that 5 synonymous and 4 non-synonymous variants were found. The variant
c.595C>A (p.Pro199Thr) was found in 40 dogs, and the gene frequency was significantly
higher in dogs with higher body condition scores, i.e. 0.320 in BCS4–5 dogs, 0.175 in BCS3
dogs and 0.000 in BCS2 dogs. We conclude that c.595C>A (p.Pro199Thr) is a candidate
variant relating to obesity, which may be helpful for nutritional management of dogs. 相似文献
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Mariko Mochizuki Masahiro Osada Katsumi Ishioka Takako Matsubara Yutaka Momota Norio Yumoto Toshinori Sako Shinji Kamiya Itaru Yoshimura 《Animal Science Journal》2014,85(3):323-329
The understanding of animal products and dairy farming is important for the promotion of dairy farming. Thus, to examine the effects of farm experience on the understanding of animal products and the management of dairy farming, the interaction between students and dairy cows was investigated in groups of first‐year veterinary nursing students in 2011 and 2012 (n = 201). These students included 181 women and 20 men. Nine items about dairy cows were presented in a questionnaire. The survey was performed before and after praxis on the educational farm attached to the authors' university. After praxis on the farm, increases occurred in the number of positive responses to the items involving the price of milk, dairy farming and the taste of milk. For these items, a significant difference (P < 0.05) was found between the scores obtained before and after training. The results of the study suggested that farm experience is useful for improving the understanding of animal products and dairy farming. 相似文献
7.
Na+ Retention in the Root is a Key Adaptive Mechanism to Low and High Salinity in the Glycophyte,Talinum paniculatum (Jacq.) Gaertn. (Portulacaceae) 下载免费PDF全文
D. V. M. Assaha A. M. M. Mekawy L. Liu M. S. Noori K. S. Kokulan A. Ueda T. Nagaoka H. Saneoka 《Journal of Agronomy and Crop Science》2017,203(1):56-67
Talinum paniculatum is an important leafy vegetable and medicinal plant, used in many parts of South America, Africa and Asia. Its adaptation to abiotic stress has received little attention and therefore worthy of interest, especially as environmental conditions are rendering arable lands increasingly unfavourable for agriculture. Therefore, this study was undertaken to examine the influence of salt stress on the vegetative growth of the plant by subjecting seedlings to 0, 25, 50, 100, 200 and 300 mm NaCl stress for 10 days. The dry weight, ion concentrations, relative water content, oxidative damage, proline, osmotic potential and some antioxidants were determined. The plants were found to retain Na+ mainly in the root, with less affected leaf K+ concentration, and consequently very low shoot Na+/K+ ratios (<0.2) under all the stress treatments. The proline content significantly increased under the 100–300 mm treatments (18‐ to 244‐fold), with a corresponding significant reduction in osmotic potential and hence high osmotic adjustment. The antioxidant enzyme activities and non‐enzyme antioxidants showed significant increase only under the highest salinity. Taken together, these results suggest that shoot Na+ exclusion is characteristic of this plant and is mainly responsible for its adaptation to low salinity. 相似文献
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Aoshima H Okita Y Hossain SJ Fukue K Mito M Orihara Y Yokoyama T Yamada M Kumagai A Nagaoka Y Uesato S Hara Y 《Journal of agricultural and food chemistry》2005,53(6):1955-1959
Recently, 3-O-octanoyl-(+)-catechin (OC) was synthesized from (+)-catechin (C) by incorporation of an octanoyl chain into C in the light of (-)-epicatechin gallate (ECg) and (-)-epigallocatechin gallate (EGCg), which are the major polyphenols found in green tea and have strong physiological activities. OC was found to inhibit the response of ionotropic gamma-aminobutyric acid (GABA) receptors (GABA(A) receptors) and Na+/glucose cotransporters expressed in Xenopus oocytes in a noncompetitive manner more strongly than does C. OC also induced a nonspecific membrane current and decreased the membrane potential of the oocyte, and thus death of the oocyte occurred even at lower concentrations than that induced by C or EGCg. Although EGCg produced H2O2 in aqueous solution, OC did not. This newly synthesized catechin derivative OC possibly binds to the lipid membrane more strongly than does C, Ecg, or EGCg and as a result perturbs the membrane structure. 相似文献
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