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排序方式: 共有103条查询结果,搜索用时 15 毫秒
1.
Catherine Bouchard Erin Leonard Jules Konan Koffi Yann Pelcat Andrew Peregrine Neil Chilton Kateryn Rochon Tim Lysyk L. Robbin Lindsay Nicholas Hume Ogden 《The Canadian veterinary journal. La revue veterinaire canadienne》2015,56(7):693-699
There is an increasing risk of Lyme disease in Canada due to range expansion of the tick vector, Ixodes scapularis. The objectives of this article are to i) raise public awareness with the help of veterinarians on the emerging and expanding risk of Lyme disease across Canada, ii) review the key clinical features of Lyme disease in dogs, and iii) provide recommendations for veterinarians on the management of Lyme disease in dogs. 相似文献
2.
Population pharmacokinetics of methadone hydrochloride after a single intramuscular administration in adult Japanese sika deer (Cervus nippon nippon) 下载免费PDF全文
Christopher Scala Amélie Marsot Marie‐Josée Limoges Yann Locatelli Nicolas Simon Jean‐Claude Alvarez 《Veterinary anaesthesia and analgesia》2015,42(2):165-172
ObjectiveTo assess the population pharmacokinetics of methadone in deer.Study designProspective non-randomized experimental trial.AnimalsTwelve healthy adult sika deer (nine males and three females).MethodsDeer received intramuscular administration of racemic methadone hydrochloride at 0.5 mg kg−1 or 1 mg kg−1. Plasma methadone and its metabolite 2-Ethylidene-1,5-Dimethyl-3,3-Diphenyl-Pyrolidine (EDDP) concentrations were determined by validated liquid chromatography coupled to tandem mass spectrometry methods, at times 0, 30 minutes, 1, 2, 3, 4, 5, 6, 8, 12 and 24 hours. Population pharmacokinetics analysis was undertaken using a non-linear mixed effects modelling (NONMEM).ResultsA two-compartment linear disposition model best described observed time-concentration profiles of methadone and EDDP. Population parameter estimates of methadone were elimination clearance (17.3 L hour−1), metabolic clearance (34.6 L hour−1), volume of distribution of compartment 1 (216.0 L) and volume of distribution of compartment 2 (384.0 L). Population parameter estimates of EDDP were elimination clearance (121.0 L hour−1), volume of distribution of compartment 3 (1.08 L) and volume of distribution of compartment 4 (499.5 L). The total clearance and total volume of distribution of methadone and EDDP were 51.9 L hour−1, 121.0 L hour −1, 600.0 L and 500.6 L, respectively. The methadone terminal elimination half-life was 8.19 hours. No adverse effects were observed after methadone administration.Conclusions and Clinical relevanceFollowing intramuscular injection, methadone was characterized by a large total volume of distribution, high systemic clearance and intermediate terminal half-life in sika deer. 相似文献
3.
New Forests - Between the nineteenth and early twentieth centuries, large-scale afforestation projects were undertaken in the Swiss Prealps. The Swiss stone pine (Pinus cembra L.), an emblematic... 相似文献
4.
Romain Gastineau Fran?ois Turcotte Jean-Bernard Pouvreau Michèle Moran?ais Jo?l Fleurence Eko Windarto Fiddy Semba Prasetiya Sulastri Arsad Pascal Jaouen Mathieu Babin Laurence Coiffard Céline Couteau Jean-Fran?ois Bardeau Boris Jacquette Vincent Leignel Yann Hardivillier Isabelle Marcotte Nathalie Bourgougnon Réjean Tremblay Jean-Sébastien Deschênes Hope Badawy Pamela Pasetto Nikolai Davidovich Gert Hansen Jens Dittmer Jean-Luc Mouget 《Marine drugs》2014,12(6):3161-3189
In diatoms, the main photosynthetic pigments are chlorophylls a and c, fucoxanthin, diadinoxanthin and diatoxanthin. The marine pennate diatom Haslea ostrearia has long been known for producing, in addition to these generic pigments, a water-soluble blue pigment, marennine. This pigment, responsible for the greening of oysters in western France, presents different biological activities: allelopathic, antioxidant, antibacterial, antiviral, and growth-inhibiting. A method to extract and purify marennine has been developed, but its chemical structure could hitherto not be resolved. For decades, H. ostrearia was the only organism known to produce marennine, and can be found worldwide. Our knowledge about H. ostrearia-like diatom biodiversity has recently been extended with the discovery of several new species of blue diatoms, the recently described H. karadagensis, H. silbo sp. inedit. and H. provincialis sp. inedit. These blue diatoms produce different marennine-like pigments, which belong to the same chemical family and present similar biological activities. Aside from being a potential source of natural blue pigments, H. ostrearia-like diatoms thus present a commercial potential for aquaculture, cosmetics, food and health industries. 相似文献
5.
Oberstrass FC Auweter SD Erat M Hargous Y Henning A Wenter P Reymond L Amir-Ahmady B Pitsch S Black DL Allain FH 《Science (New York, N.Y.)》2005,309(5743):2054-2057
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor. 相似文献
6.
灌溉水资源的短缺已成为干旱半干旱地区农业持续发展的一个重要限制因素,咸水资源的开发利用可有效的解决灌溉水源短缺的问题。从咸水灌溉对作物、生态环境的影响、咸水灌溉技术以及咸水灌溉条件下的改良等方面总结了国内外咸水资源灌溉利用的研究进展,为合理的利用咸水资源进行灌溉提供指导。从咸水资源灌溉利用现状来看,膜下滴灌为干旱半干旱地区有效的利用咸水和微咸水资源以及盐碱地的开发利用提供了有效的手段。但利用膜下滴灌方式进行咸水灌溉,目前仍存在一些问题,需要进一步研究。此外,如何从流域或区域尺度上评价咸水灌溉的影响,并从更大尺度维持盐分平衡及环境的可持续发展值得深入研究。 相似文献
7.
Jean-Pierre Wigneron Jean-Christophe Calvet Yann Kerr 《Agricultural and Forest Meteorology》1996,80(2-4)
In the present work, the time variations of a wheat field microwave emission are analysed during irrigation phases. The aim of the study is to investigate the use of low-frequency microwave measurements to monitor hydrological variables over a wheat crop: surface soil moisture and water interception by the vegetation canopy. The irrigation phases were representative of rainfall or dew events. It appears that the radiometric measurements are strongly sensitive to the hydrological characteristics of the soil and of the vegetation canopy. The 1.4GHz measurements are mainly sensitive to surface soil moisture mv, whereas the 5 GHz measurements are sensitive to both mv and to the vegetation water content Wv. A simple model approach is implemented to retrieve simultaneously these two surface parameters. The results of this procedure show the high potential of the microwave remote sensing measurements to monitor the time variations of soil moisture and of the total vegetation water content. The value of the wheat water storage capacity is derived from the microwave measurements and is in good agreement with experimental data. 相似文献
8.
Stéphane Mombo Yann Foucault Frédéric Deola Irène Gaillard Sylvaine Goix Muhammad Shahid Eva Schreck Antoine Pierart Camille Dumat 《Journal of Soils and Sediments》2016,16(4):1214-1224
Purpose
At the global scale, gardening activities are often performed in urban areas with a historical background of pollution. In this study, a participatory program was developed with citizens concerned by gardening activities near a 50-year-old regulated lead recycling company, with the aim of co-constructing the tools for the assessment and management of potential sanitary risks induced by historic pollution with persistent (eco) toxic metals: lead and cadmium.Materials and methods
Soils and vegetables (lettuce, leek, celery, carrot, chard, pumpkin, and celeriac) samples were collected from four kitchen gardens neighboring a 50-year-old secondary lead smelter. Both total and in vitro human bioaccessible metal concentrations in the cultivated plants were measured in relation to soil characteristics.Results and discussion
The results showed that the soils of these gardens were slightly contaminated by metals (Pb, 77 to 236 mg kg?1; and Cd, 0.5 to 1 mg kg?1) in comparison with the natural geologic background. However, significant pollution of vegetables can occur especially with lead (Pb up to 9.8 mg kg?1 in lettuce) and certainly as a result of direct foliar transfer. The washing of plants before consumption is therefore recommended in the context of atmospheric fallout of ultrafine particles enriched with metals.Conclusions
Metal bioaccessibility measure integrates the influence of metal type, plant type, and soil physico-chemical properties. Based on the results, it is proposed that human bioaccessible fraction of metals may also be currently taken into account as well as total metal quantities and bioaccumulation factors in risk assessment studies performed in gardens. Overall, this study has led to reflections and functional recommendations aimed at reducing human exposure and to finally developing sustainable gardening practices.9.
[目的] 测度土地利用碳排放效应,探索土地利用与碳排放之间的脱钩关系,进而揭示土地利用变化的碳排放规律,为制定资源保护和生态文明政策提供科学依据。[方法] 以中国农业典型生产中心地区、中国人口大省——河南省为研究区域,基于近20 a间土地利用现状遥感监测数据,从县域尺度研究土地利用碳排放和土地利用强度的时空格局演变特征,并借助于脱钩分析的理论框架来检测它们之间的脱钩关系。[结果] ①在研究期间,碳排放呈现出明显的空间异质性。豫中地区、豫北地区碳排放水平明显高于其他区域;平原地区和大城市周边地区的碳排放明显高于山区和丘陵地区。②研究期间土地利用强度持续增加,豫中地区土地利用强度明显高于豫南地区,而豫北地区土地利用强度分布表现出明显的空间集聚现象。③研究期间土地利用强度和碳排放二者的主要关系类型为扩张负脱钩和强脱钩,需要从资源高消耗、高碳排放的双高模式不断向资源低消耗、低碳排放的低碳发展模式转变。[结论] 不同阶段、不同地区在土地利用强度与碳排放之间的脱钩关系程度方面有着明显差异,应采用差异性管控政策,促进生态环境保护和经济发展之间形成协调稳定的发展关系。 相似文献
10.