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Campera Marco Budiadi Budiadi Bušina Tomáš Fathoni Baladzuri Hafizh Dermody Janine Nijman Vincent Imron Muhammad Ali Nekaris K. A. I. 《Agroforestry Systems》2022,96(5-6):829-841
Agroforestry Systems - Complex agroforestry systems are suggested as a possible solution to reduce the effects of deforestation in the tropics while enhancing the livelihoods of local human... 相似文献
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Kuss SK Best GT Etheredge CA Pruijssers AJ Frierson JM Hooper LV Dermody TS Pfeiffer JK 《Science (New York, N.Y.)》2011,334(6053):249-252
Intestinal bacteria aid host health and limit bacterial pathogen colonization. However, the influence of bacteria on enteric viruses is largely unknown. We depleted the intestinal microbiota of mice with antibiotics before inoculation with poliovirus, an enteric virus. Antibiotic-treated mice were less susceptible to poliovirus disease and supported minimal viral replication in the intestine. Exposure to bacteria or their N-acetylglucosamine-containing surface polysaccharides, including lipopolysaccharide and peptidoglycan, enhanced poliovirus infectivity. We found that poliovirus binds lipopolysaccharide, and exposure of poliovirus to bacteria enhanced host cell association and infection. The pathogenesis of reovirus, an unrelated enteric virus, also was more severe in the presence of intestinal microbes. These results suggest that antibiotic-mediated microbiota depletion diminishes enteric virus infection and that enteric viruses exploit intestinal microbes for replication and transmission. 相似文献
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