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1.
Anticoagulant effects of low-molecular-weight heparins in healthy cats   总被引:4,自引:0,他引:4  
BACKGROUND: Low-molecular-weight heparin (LMWH) has potential benefit in cats at risk for thromboembolic disease. However, LMWH pharmacokinetics has not been characterized in the cat. Drug effect with LMWH may be evaluated with analysis of factor Xa inhibition (anti-Xa) or thromboelastography (TEG). HYPOTHESIS: Administration of LMWH at previously recommended dosages and schedules to healthy cats will result in inhibition of factor Xa and hypocoagulable TEG. ANIMALS: In vivo research with heparin was performed in 5 purpose-bred cats. METHODS: In a prospective study with randomized crossover design, heparin or placebo was administered. Treatments were unfractionated heparin (UFH), 250 IU/kg q6h; dalteparin, 100 IU/kg q12h; enoxaparin, 1 mg/kg q12h; or 0.9% saline, 0.25 mL/kg q6h. Each drug was administered for 5 consecutive days followed by a minimum washout of 14 days. Baseline and post-treatment analyses included anti-Xa, TEG, and prothrombin time/activated partial thromboplastin time. RESULTS: Mean anti-Xa activity 4 hours after enoxaparin (0.48 U/mL) approached the human therapeutic target (0.5-1.0 U/mL); however, mean trough anti-Xa activity was below detection limits. Mean anti-Xa activity 4 hours after dalteparin was lower, and only 1 cat attained therapeutic target at a single time point. Cats receiving UFH attained target anti-Xa activity and changes in TEG at trough and 4 hours. CONCLUSIONS: Cats have rapid absorption and elimination kinetics with LMWH therapy. On the basis of pharmacokinetic modeling, cats will require higher dosages and more frequent administration of LMWH to achieve human therapeutic anti-factor Xa activity of 0.5-1 U/mL. Peak anti-Xa activity is predicted at 2 hours after administration of LMWH.  相似文献
2.
Atypical primary ocular melanoma in cats   总被引:2,自引:2,他引:1  
The clinical and pathologic features of six cases of atypical primary ocular melanoma in cats are described. In contrast to diffuse iris melanomas, these atypical tumors originated multifocally from any portion of the uvea and in five of the six cases were very advanced at the time of clinical presentation. Two of the advanced cases involved primarily the ciliary body, while three others showed extensive involvement of the choroid. Histologically, these tumors consisted primarily of round, heavily pigmented cells lacking the anaplastic nuclear features characteristic of advanced diffuse iris melanomas. The advanced stage of the tumors at presentation may have been due to either the posterior uveal origin of these tumors or to more rapid progression. Additional cases with long-term follow-up need to be studied in order to accurately assess the biological behaviour of these tumors.  相似文献
3.
Helical computed tomography angiography was used to evaluate the renal vascular anatomy of potential feline renal donors. One hundred and fourteen computed tomography angiograms were reviewed. The vessels were characterized as single without bifurcation, single with bifurcation, double, or triple. Multiplicity was most commonly seen for the right renal vein (45/114 vs. 3/114 multiple left renal veins, 0/114 multiple right renal arteries, and 8/114 multiple left renal arteries). The right kidney was 13.3 times more likely than the left to have multiple renal veins. Additional vascular variants included double caudal vena cava and an accessory renal artery. For the left kidney, surgery and computed tomography angiography findings were in agreement in 92% of 74 cats. For the right kidney, surgery and computed tomography angiography findings were in agreement in 6/6 cats. Our findings of renal vascular anatomy variations in cats were similar to previous reports in humans. Identifying and recognizing the pattern of distribution of these vessels is important when performing renal transplantation.  相似文献
4.
猫细小病毒、犬细小病毒、貂细小病毒的特征比较   总被引:1,自引:1,他引:1       下载免费PDF全文
猫细小病毒、犬细小病毒和貂细小病毒是3种极为相似的细小病毒。最初人们主要根据患病水貂、猫、犬临床症状相似的特点,注意到它们之间可能有密切关系。时至今日,对这3种病毒的许多方面都已进行了深入的研究。作者从猫细小病毒、犬细小病毒、貂细小病毒病共同特性、生物学差异和进化机制等方面对这3种病毒的特征进行了比较和综述。  相似文献
5.
虎源猫瘟热病毒VP2蛋白特异性单克隆抗体的制备   总被引:1,自引:1,他引:0  
以原核表达的虎源猫瘟热病毒(FPV)VP2蛋白作为免疫抗原,免疫6周龄BALB/c小鼠,用FPV全病毒作为筛选抗原,采用淋巴细胞杂交瘤技术,经过有限稀释法获得了1株可稳定分泌抗虎源FPVVP2蛋白的杂交瘤细胞株3C4。间接ELISA方法测定3C4株单抗腹水效价为1∶12800,亚类鉴定为IgG2a类型,间接免疫荧光试验显示该株单抗能与虎源FPV发生反应,而免疫印迹试验该株单抗未见特异性反应带。  相似文献
6.
猫细小病毒CC 1株VP1基因克隆与序列分析   总被引:1,自引:1,他引:0       下载免费PDF全文
根据GenBank登录的猫细小病毒(CU-4)VP1基因序列,设计了1对引物,用PCR技术对VP1基因进行整体扩增,将扩增产物纯化后克隆入PGM-T载体,通过酶切、PCR和测序进行验证。结果表明,测序拼接得出VP1基因的序列长度约为2306 bp,该基因的ORF总长为2184 bp,编码727个氨基酸,应用DNAStar软件把所测得的序列与国内外代表性毒株的VP1基因编码区全长核苷酸序列和氨基酸序列进行比对分析,发现CC-1株与国内XJ-1株的核苷酸和氨基酸同源性均为99.3%。  相似文献
7.
猫细小病毒CC-1株VP1基因克隆与序列分析   总被引:1,自引:1,他引:0  
根据GenBank登录的猫细小病毒(CU-4)VP1基因序列,设计了1对引物,用PCR技术对VP1基因进行整体扩增,将扩增产物纯化后克隆入PGM-T载体,通过酶切、PCR和测序进行验证。结果表明,测序拼接得出VP1基因的序列长度约为2306 bp,该基因的ORF总长为2184 bp,编码727个氨基酸,应用DNAStar软件把所测得的序列与国内外代表性毒株的VP1基因编码区全长核苷酸序列和氨基酸序列进行比对分析,发现CC-1株与国内XJ-1株的核苷酸和氨基酸同源性均为99.3%。  相似文献
8.
A 3-year-old Himalayan cat was diagnosed with concurrent eosinophilic conjunctivitis, herpes virus, and a conjunctival mast cell tumor. Eosinophilic conjunctivitis was verified via cytology from a conjunctival scraping, which revealed 50% eosinophils and 50% neutrophils. Herpes virus was verified via a positive polymerase chain reaction (PCR). Conjunctival scrapings for chlamydia immmunofluorescent antibody (IFA) and herpes IFA were negative. A mycoplasma was detected by a general mycoplasma PCR but the organism did not grow on the available mycoplasma media. The mass was excised and microscopic evaluation revealed a histiocytic mast cell tumor. The mast cell did not recur following local excision (at 1 year follow-up). The eosinophilic conjunctivitis was treated with both topical steroids and systemic megesterol acetate (Ovaban). When topical steroids were used, the herpes virus flared up and resulted in dendritic and geographic corneal ulceration. Therefore, the cat was treated with megesterol acetate and the eosinophilic conjunctivitis was well controlled. Treatment of eosinophilic conjunctivitis in the cat with megesterol acetate may be the treatement of choice due to the possibility of herpes virus.  相似文献
9.
Ultrasound biomicroscopy of the feline anterior segment   总被引:1,自引:1,他引:1  
Ultrasound biomicroscopy was performed on enucleated feline globes as a model for use in vivo. Quantitative measurements were obtained from the anterior segment using a 50-MHz transducer. Mean values from 26 feline globes were axial corneal thickness, 0.74 mm; anterior chamber depth, 4.20 mm; distance from the first ciliary process to the limbus, 3.17 mm; angle recess, 0.38 mm; angle opening distance, 1.05 mm; iris base width 0.38 mm; iris middle width 0.52 mm; iris tip width 0.13 mm, and iris-lens overlap, 0.69 mm. Distinctive features of the feline anterior segment include a relatively wide iridocorneal angle and deep anterior chamber.  相似文献
10.
Abstract   An alopecia and dermatopathy following pelvic fractures associated with vehicular trauma is reported in three cats. The animals presented 3–4 weeks post injury with acute hair loss, glistening appearance of the skin and erosions involving the lower back. Histological examination revealed atrophy of the hair follicles and adnexal structures and follicular telogenization, dermal fibroplasia and mild lymphocytic infiltrate, fibroplasia and inflammation in the panniculus. Vascular damage secondary to the external trauma to blood vessels supplying the skin over the lumbar region and subsequent ischaemia may represent the pathomechanism of this type of alopecia. Focal permanent hair loss can be expected.  相似文献
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