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1.
张展  罗建平 《安徽农业科学》2013,41(13):5703-5705
[目的]研究流苏石斛水溶性多糖(WDFP)、碱溶性多糖(BDFP)及酸溶性多糖(ADFP)的理化性质与免疫活性差异,并对WD-FP的提取工艺进行优化。[方法]分别以水、碱、酸提取流苏石斛获得WDFP、BDFP和ADFP,比较3者理化性质和免疫活性;并采用响应面法优化WDFP的提取工艺条件。[结果]WDFP、BDFP和ADFP的分子量分别为2.10×105、3.34×106和3.53×106Da,特性黏度分别为68.2、134.9和40.4 ml/g。WDFP主要由葡萄糖和甘露糖组成,BDFP主要由阿拉伯糖、木糖和葡萄糖组成,ADFP主要由木糖和葡萄糖组成。WDFP免疫调节活性最高,BDFP次之,ADFP最低。WDFP最佳提取条件为:提取温度82℃,提取时间51 min,料液比1∶33.3(W/V,g/ml,下同);在此条件下,提取得率为9.68%。[结论]研究结果为流苏石斛多糖的进一步研究提供基础,为其工业化生产提供参考。  相似文献   
2.
甘草多糖对小鼠脾淋巴细胞的免疫作用   总被引:3,自引:0,他引:3  
通过体外脾淋巴细胞的培养试验,测定不同浓度的GPS对淋巴细胞的能量代谢水平和IL-2活性的影响.结果表明,添加GPS能明显增强淋巴细胞的能量代谢水平和IL-2的分泌量(P<0.01),在添加浓度为300 μg/ml时,基本上达到阳性对照组的水平(P>0.05),再继续增加浓度,测定结果没有明显的差异.表明GPS能诱导激活淋巴细胞,提高其能量代谢水平和IL-2的分泌,具有免疫调节作用.  相似文献   
3.
One new guaiane-type sesquiterpene (1) was isolated from Saussurea laniceps. The structure of the new compound was elucidated by spectroscopic data analysis. The immunomodulatory activity of compound 1 was evaluated. It was found that compound 1 showed significant inhibition for proliferation of murine T cells in vitro.  相似文献   
4.
NO分子是一种非常规的神经递质和神经调节分子,它首次被发现是由硝酸甘油在体内分解而得到的。低浓度的NO能起到扩张血管、改善心脏供血等作用,高浓度的NO具有抵抗病原体和肿瘤的作用。近年来,一氧化氮合成酶(NOS)被应用于海洋动物抵御外界病原体的研究,肯定了它在免疫防御方面的重要性。  相似文献   
5.
Ethyl acetate and chloroform extracts from aerial parts of Portulaca werdermannii and P. hirsutissima were tested in lymphoproliferation assays and axenic cultures of Leishmania amazonensis and Trypanosoma cruzi. Both extracts of P. werdermannii and P. hirsutissima had a potent inhibitory activity on lymphocyte proliferation. On the contrary, only the chloroformic extract of both plants inhibited L. amazonensis growth, without effect on T. cruzi cultures. These results indicate these Portulaca species as potential sources of new active molecules for the treatment of leishmaniasis and immune-mediated pathologies.  相似文献   
6.
Albumin (Alb), globulin (Glo), glutelin (Gll) and glutenin (Gln) were separately extracted from wheat germ and wheat gluten. Amino acisd composition, molecular weight distribution, solubility, in vitro digestibility, and immunomodulatory activities were all analyzed. Gll and Gln have similar molecular weight distributions, which differed from those of Alb and Glo. Alb showed the highest solubility at various pH values (except pH 4.0), whereas Glo showed the highest in vitro digestibility. Glo and Gll have the highest proportion of essential to total amino acids, while Alb and Gll have the highest protein digestibility-corrected amino acid scores. Gll had the strongest immunomodulatory effects in terms of stimulation of RAW 264.7 cells to produce IL-6, TNF-α, and IL-10, and good stimulatory effects on splenocyte proliferation, production of IL-2, phagocytosis, and secretion of nitric oxide in RAW 264.7 cells. Gll can be considered a good protein source for use in health foods.  相似文献   
7.
海藻是生长在海中的藻类,由数以千计的小叶海藻和大叶海藻组成。海藻含有酚类化合物、海藻多酚、海藻多糖、类胡萝卜素、脂肪酸、多肽和萜烯等生物活性物质,是有价值的生物活性分子来源。海藻还具有抗菌、抗氧化、抗炎和免疫调节功能。在猪日粮中添加海藻可以增强其免疫系统功能,有效提高免疫球蛋白数量,改善肠道健康。有效促进调节细胞因子的产生,提升机体抗氧化能力。  相似文献   
8.
The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced. Phagocytotic and mononuclear phagocytic system function assays showed that PAP stimulated the phagocytosis of phagocyte. Splenocyte proliferation assay showed that PAP acted the effect combining Con A or LPS in splenocyte proliferation. The parameters detected showed that PAP increased thymus and spleen indices, the levels of LDH and ACP in the spleen, and IL-10and IFN-γ in serum in immunosuppressed mice. The results suggest that PAP is involved in immunomodulatory effects leading to the exploration for PAP as a potential immunostimulant.  相似文献   
9.
Annona squamosa (AS) has traditionally been used as ethnomedicine. We have earlier extracted and fractionated the twigs of AS based upon its bioactivity and observed its immune potentiating activity that was localized in its three fractions. Present communication deals with the phytochemical analysis and pharmacological investigation of the most active chloroform fraction that led to isolation and identification of a number of compounds whose structures were elucidated using 1D and 2D NMR spectroscopic analysis. Amongst the twelve pure compounds isolated, five compounds Lanuginosine (1), (+) -O- methylarmepavine (2), (+)-anomuricine (3), Isocorydine (4), and N-methyl-6, 7-dimethoxyisoquinolone (5) were evaluated in vivo for their immune modifier activities in BALB/c mice after oral administration at three log doses of 0.3, 1.0 and 3.0 mg/kg for 14 consecutive days. Of these, three compounds (1, 2 and 5) showed dose dependent immune stimulating activity. However, the uppermost activity was noted in the compound N-methyl-6, 7-dimethoxyisoquinolone at the 3.0 mg/kg oral dose. The activity was assessed in the form of increased splenic T and B cellular proliferation, up-regulated CD4+, CD8+ and CD19+ cell population and accentuation in the peritoneal macrophage function. The compound possibly acted modifying the expression of Th1- and Th2- cytokines via stimulation of pro-inflammatory Th1 cytokines IL-2 and IFN-γ. These results warrant the use of the above compounds as an efficient immune-stimulant or immune-adjuvant against diseases with immune suppression. The analogs of the compound may further be chemically synthesized to achieve desired immune modifying activity.  相似文献   
10.
Immunomodulatory activity of water and acetone extracts of stem bark of Pouteria cambodiana was examined on murine macrophage phagocytosis [nitroblue tetrazolium (NBT) dye reduction and lysosomal enzyme activity] and proliferation of splenocytes and bone marrow cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay with and without lipopolysaccharide (LPS) or pokeweed mitogen (PWM). Both aqueous and acetone extracts presented immunomodulatory activity without clear dose response relationship.  相似文献   
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