Intestinal absorption of forsythoside A in different compositions of Shuang-Huang-Lian

Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h^− 1) of forsythoside A in FF + LSF, FF + SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C_max and AUC_0 → 1440 of forsythoside A all increased and T_1/2 prolonged in SHL, FF + LJF and FF + SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver.     

Construction of a novel densitometer that utilizes a near-infrared laser system with Douglas fir (Pseudotsuga menziesii)

Abstract

A novel densitometer consisting of a continuous wave near-infrared (NIR) laser source and an avalanche photodiode module as the detector has been designed, which can rapidly and non-destructively measure the density of wood. The wood density of a small area (3.14 mm²) at the radial-transverse face was continuously estimated using the intensity of the transmitted light with the aid of the modified Lambert-Beer law. By conducting a validity evaluation with statistical coefficients, it was shown that the constructed system could obtain the sharp density profile compatible with X-ray densitometer [Root mean squared error of calibration (RMSEC) = 0.045 g cm^?3, Root mean squared error of validation (RMSEV) = 0.046 g cm^?3). It was concluded that the constructed NIR device has high performance from the viewpoint of operability, measuring time and safety.     

小型猪复合麻醉剂对大鼠不同脑区突触体Ca^2＋，Mg^2＋-ATP酶活性的影晌

探讨Ca2＋，Mg2＋-ATP酶与小型猪复合麻醉剂全麻作用的关系，以判断该酶是否为该制剂作用的靶位之一。选取84只SD大鼠，先随机抽取12只为对照组，其余随机均分为高剂量小型猪复合麻醉剂组（腹腔注射7．5mg／kg）和低剂量小型猪复合麻醉剂组（腹腔注射5mg／kg），每个剂量组又随机均分为麻醉组、恢复I组和恢复Ⅱ组等3个亚纽。对照组腹腔注射生理盐水10mL／kg，5min后断头取材；麻醉组、恢复I组和恢复Ⅱ组分别在翻正反射消失即刻、翻正反射恢复即刻和大鼠可直线爬行后断头取材，在生理盐水冰面上取脑，用4℃生理盐水将脑上的血迹冲洗干净，迅速分离双侧大脑皮层、海马、小脑、脑干、丘脑，立即液氮冷冻。制备脑粗突触体，采用比色法测定ca2＋，Mg2-ATP酶活性。结果表明，小型猪复合麻醉剂的全麻作用与抑制小脑和丘脑突触体Ca2＋，Mg2＋-ATP酶活性相关，此酶可能是小型猪复合麻醉剂全麻作用的靶位之一。     

Decreasing detection frequency of MITE(MCLas-A) in the population of ‘Candidatus Liberibacter asiaticus' recently collected in southern China

An active miniature inverted-repeat transposable element(MITE), MCLas-A, was previously identified from ‘Candidatus Liberibacter asiaticus' known to be associated with citrus Huanglongbing(HLB, yellow shoot disease). To explore the recent transposition status of MCLas-A, 389 ‘Ca. L. asiaticus' strains collected from nine regions in China were amplified using a specific primer set and three representative ‘Ca. L. asiaticus' strains were analyzed by next-generation sequencing(NGS) approach. PCR and genomic analysis showed that the entire MCLas-A was only present in 1.80%(7/389) and the jumping-out type of the MITE was predominant(81.23%) in samples tested, suggesting high frequency transposition occurred in ‘Ca. L. asiaticus' strains recently collected from China. Biological roles of transposition of the active MITE remain to be determined.     

不同波长选择方法在土壤有机质含量检测中对比研究

由于近红外光谱数据的多重共线性，特征波长选择一直是近红外光谱分析技术的重要研究内容。以108个土壤样本光谱数据和土壤有机质(SOM)含量为研究对象，以连续投影算法（SPA）、间隔偏最小二乘法（IPLS）、竞争自适应重加权采样法（CARS）三种典型的特征波长选择算法进行近红外光谱波长选择和土壤有机质含量建模。研究结果表明，基于上述三种方法提取的特征波长所建立的模型预测能力均优于全谱模型。其中，基于SPA算法的MLR预测模型精度最优，预测集相关系数（Rp）和均方根误差（RMSEP）分别为0970 2和1.214 4，模型参数只有6个。因此，SPA-MLR可以有效地应用近红外光谱的建模，并且简化模型的复杂度，提高模型的计算效率。     

宁夏玉米营养成分近红外分析模型建立与应用

研究采集宁夏区内各市县(固原、海原、同心、中卫、中宁、永宁、平罗)抽取玉米样品120批,用近红外分析仪扫描定标样品集获得玉米近红外光谱图,利用偏最小二乘法建立模型,并分别经过无预处理、均值中心化、标准正态变量转换、一阶导数、标准正态变量转换结合去趋势校正(SNV+D)预处理光谱,获得水分、粗蛋白、粗脂肪、粗纤维预测模型,分别是经过MC、SNV+D、SNV+D、SNV+D光谱预处理后效果最好。预测决定系数R² _p分别为0.951、0.976、0.728、0.897,相对分析误差RPD除粗脂肪为2.62外,其他均大于3的近红外预测模型,通过预测模型验证集验证后,并对模型预测值与实测值进行U检验,结果为差异不显著(P>0.05)。该近红外预测模型对玉米中水分、粗蛋白、粗纤维具有较佳预测效果,粗脂肪的预测精度有待进一步提高。     

不同合成树脂工艺对改性材性能影响研究

为研究树脂对改性材性能的影响，采用2种不同工艺合成三聚氰胺-脲醛树脂（MUF），测试了树脂的相关性能。结果表明，不同合成工艺路线下制备的 MUF 树脂在固体含量、粘度、固化时间、游离甲醛含量间存在显著差异。最终树脂的分子结构类型相似性极高，但相同结构组分在不同树脂中所占比例各有差异。羟甲基基团在MUF2中所占比例高，而亚甲基桥键及醚键在MUF1中含量高。MUF1改性材的增重率（weight percent gain，WPG）值更大，但MUF2改性材的抗溶胀性（anti-swelling efficiency，ASE）和体积膨胀率（bulking rates，B）更高，MUF2改性材的尺寸稳定性更好。     

基于结构模块化的微型山地稻麦联合收割机设计

机型及价格因素是制约山地丘陵地区水稻联合收割机普及的重要因素。通过适当删除一些不适合微型机的工艺流程、合理地布置整机各功能部件等措施,实现了机器的微型化设计。通过模块的划分和组合实现了机器的模块化设计,为快速配置不同性能的机器提供了一种实现方案。